{"title":"补充维生素D对妊娠期糖尿病患者血糖控制和血脂的影响:一项随机对照试验的荟萃分析","authors":"Yu Bai, Lei Tang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.04.003","DOIUrl":null,"url":null,"abstract":"Objective \nTo systematically evaluate the effects of vitamin D supplementation on glucose homeostasis parameters and lipid profiles in gestational diabetes patients. \n \n \nMethods \nFour main databases including PubMed, Web of Science, CNKI and Wanfang were searched to collect randomized controlled trials (RCTs) about vitamin D supplementation for gestational diabetes mellitus from inception to February 1, 2018.Two investigators were chosen to search, extract and evaluate the data independently. Software RevMan 5.3 and Stata 15.0 were used for meta-analysis. \n \n \nResults \nResults A total of 6 randomized RCTs were included including 409 patients totally which were divided into two groups as study group(n=204) and control group(n=205). The results showed that compared with the control group, patients in study group had lower fasting plasma glucose(FPG)[MD=-11.43, 95% CI=(-15.24-7.61), P=0.000 01], fasting insulin(FIns)[MD=-4.8, 95% CI=(-5.99, 3.62), P<0.000 01], insulin homeostasis model assessment of insulin resistance(HOMA-IR)[MD=-1.48, 95% CI=(-1.81, 1.16), P<0.000 01], total-cholesterol(TC)[MD=-14.09, 95% CI=(-22.09, 5.2), P=0.002], low-density lipoprotein(LDL)[MD=-10.54, 95% CI=(-18.18, 2.89), P=0.007] and high-density lipoprotein(HDL)[MD=2.11, 95% CI=(0.36, 3.86), P=0.02]. No significant difference was found in triglycerides level(TG) between the two groups. \n \n \nConclusion \nVitamin D supplementation in patients with gestational diabetes can improve FPG, insulin, TC, LDL, insulin resistance and HDL, but has no effect on TG. \n \n \nKey words: \nVitamin D; Gestational diabetes mellitus; Meta-analysis; Randomized controlled trials","PeriodicalId":9877,"journal":{"name":"中华临床营养杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of vitamin D supplementation on glycaemic control and lipid profiles in gestational diabetes mellitus: a Meta-analysis of randomized controlled trials\",\"authors\":\"Yu Bai, Lei Tang\",\"doi\":\"10.3760/CMA.J.ISSN.1674-635X.2019.04.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo systematically evaluate the effects of vitamin D supplementation on glucose homeostasis parameters and lipid profiles in gestational diabetes patients. \\n \\n \\nMethods \\nFour main databases including PubMed, Web of Science, CNKI and Wanfang were searched to collect randomized controlled trials (RCTs) about vitamin D supplementation for gestational diabetes mellitus from inception to February 1, 2018.Two investigators were chosen to search, extract and evaluate the data independently. Software RevMan 5.3 and Stata 15.0 were used for meta-analysis. \\n \\n \\nResults \\nResults A total of 6 randomized RCTs were included including 409 patients totally which were divided into two groups as study group(n=204) and control group(n=205). The results showed that compared with the control group, patients in study group had lower fasting plasma glucose(FPG)[MD=-11.43, 95% CI=(-15.24-7.61), P=0.000 01], fasting insulin(FIns)[MD=-4.8, 95% CI=(-5.99, 3.62), P<0.000 01], insulin homeostasis model assessment of insulin resistance(HOMA-IR)[MD=-1.48, 95% CI=(-1.81, 1.16), P<0.000 01], total-cholesterol(TC)[MD=-14.09, 95% CI=(-22.09, 5.2), P=0.002], low-density lipoprotein(LDL)[MD=-10.54, 95% CI=(-18.18, 2.89), P=0.007] and high-density lipoprotein(HDL)[MD=2.11, 95% CI=(0.36, 3.86), P=0.02]. No significant difference was found in triglycerides level(TG) between the two groups. \\n \\n \\nConclusion \\nVitamin D supplementation in patients with gestational diabetes can improve FPG, insulin, TC, LDL, insulin resistance and HDL, but has no effect on TG. \\n \\n \\nKey words: \\nVitamin D; Gestational diabetes mellitus; Meta-analysis; Randomized controlled trials\",\"PeriodicalId\":9877,\"journal\":{\"name\":\"中华临床营养杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华临床营养杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.04.003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Nursing\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华临床营养杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.04.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Nursing","Score":null,"Total":0}
Effects of vitamin D supplementation on glycaemic control and lipid profiles in gestational diabetes mellitus: a Meta-analysis of randomized controlled trials
Objective
To systematically evaluate the effects of vitamin D supplementation on glucose homeostasis parameters and lipid profiles in gestational diabetes patients.
Methods
Four main databases including PubMed, Web of Science, CNKI and Wanfang were searched to collect randomized controlled trials (RCTs) about vitamin D supplementation for gestational diabetes mellitus from inception to February 1, 2018.Two investigators were chosen to search, extract and evaluate the data independently. Software RevMan 5.3 and Stata 15.0 were used for meta-analysis.
Results
Results A total of 6 randomized RCTs were included including 409 patients totally which were divided into two groups as study group(n=204) and control group(n=205). The results showed that compared with the control group, patients in study group had lower fasting plasma glucose(FPG)[MD=-11.43, 95% CI=(-15.24-7.61), P=0.000 01], fasting insulin(FIns)[MD=-4.8, 95% CI=(-5.99, 3.62), P<0.000 01], insulin homeostasis model assessment of insulin resistance(HOMA-IR)[MD=-1.48, 95% CI=(-1.81, 1.16), P<0.000 01], total-cholesterol(TC)[MD=-14.09, 95% CI=(-22.09, 5.2), P=0.002], low-density lipoprotein(LDL)[MD=-10.54, 95% CI=(-18.18, 2.89), P=0.007] and high-density lipoprotein(HDL)[MD=2.11, 95% CI=(0.36, 3.86), P=0.02]. No significant difference was found in triglycerides level(TG) between the two groups.
Conclusion
Vitamin D supplementation in patients with gestational diabetes can improve FPG, insulin, TC, LDL, insulin resistance and HDL, but has no effect on TG.
Key words:
Vitamin D; Gestational diabetes mellitus; Meta-analysis; Randomized controlled trials