耐力运动员(长跑运动员)和力量/耐力运动员(摔跤运动员、足球运动员)过氧化物酶体增殖物激活受体α基因的遗传差异

IF 0.3 Q4 HEALTH CARE SCIENCES & SERVICES
Melahat Kurtuluş, Kadir Keskin, M. Gunay, T. Kesi̇ci̇, K. Gökdemi̇r
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引用次数: 0

摘要

引言:过氧化物酶体增殖物激活受体α基因在脂肪酸、葡萄糖和能量代谢相关基因的表达中起着重要作用。PPARα内含子7G/C多态性(rs4253778)是与运动成绩相关的基因之一。本研究旨在调查耐力导向型运动员(长跑运动员)、力量/耐力导向型(摔跤运动员和足球运动员)(n=158)和非运动个体(n=56)PPARαG/C的基因型分布和等位基因频率。材料与方法:采用聚合酶链式反应和限制性片段长度多态性分析方法,对PPARα内含子7G/C基因多态性进行分析。结果:比较了耐力导向型运动员(长跑运动员)和力量/耐力导向型(摔跤运动员和足球运动员)根据运动学科分类的PPARα内含子7G/C的基因型和等位基因频率。此外,还将运动员与非运动员进行了比较。PPARα内含子7G/C基因型和等位基因频率在运动员组和非运动员组中相似(p<0.05),结论:PPARα基因多态性在耐力和混合运动学科中可能不是一个独特的遗传标志。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic Differences in Peroxisome Proliferator-Activated Receptor Alpha Gene in Endurance Athletes (Long Distance Runners) and Power/Endurance Athletes (Wrestlers, Football Players)
Introduction: Peroxisome proliferator-activated receptor alpha gene plays an important role in the expression of genes involved in fatty acid, glucose, and energy metabolism. PPARα intron 7 G/C polymorphism (rs4253778) is one of the genes associated with athletic performance. This study aimed to investigate the genotype distribution and allele frequencies of PPARα G/C of endurance-oriented athletes (long-distance runners) and power/endurance-oriented athletes (wrestlers and football players) (n=158) and non-athletic individuals (n=56). Material and Methods: PPARα intron 7 G/C gene polymorphism was analyzed using the polymerase chain reaction and restriction fragment length polymorphism methods. Results: Genotypes and allele frequencies of PPARα intron 7 G/C were compared between endurance-oriented athletes (long-distance runners) and power/endurance-oriented athletes (wrestlers, and football players) categorized according to their sport disciplines. In addition, athletes were compared to non-athletic individuals. The genotype and allele frequencies of PPARα intron 7 G/C were similar in the groups of athlete and non-athletic individuals (p˃0.05). There was no statistically significant association in genotype distribution and allele frequencies of the PPARα gene among endurance-oriented athletes, power/endurance-oriented athletes, and non-athletic individuals (p˃0.05). Conclusion: The PPARα gene polymorphism may not be considered as a distinctive genetic marker in endurance and mixed sport disciplines.
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来源期刊
Journal of Basic and Clinical Health Sciences
Journal of Basic and Clinical Health Sciences HEALTH CARE SCIENCES & SERVICES-
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50.00%
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