帕金森病药物治疗的最新指南

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL
Tomasz Karabin, G. Biała, M. Kruk-Slomka
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引用次数: 0

摘要

摘要帕金森病(PD)是中枢神经系统(CNS)最常见的疾病之一。PD是一种与年龄相关的疾病,发病率随着年龄的增长而增加。它的主要症状是运动迟缓、僵硬和静息性震颤等运动症状。这些症状会降低患者生活的舒适度,并可能导致行动不便。因此,快速诊断和开始治疗非常重要。PD的药物治疗是困难的。PD涉及多巴胺能和胆碱能系统之间的不平衡。因此,目前可用的药物的作用机制与PD的病理高度相关,并遵循多巴胺能或抗胆碱能控制策略。然而,长期使用许多PD药物会带来严重的副作用。因此,寻找新的、更有效的药物涉及到不同的策略和不同的目标仍在进行中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The recent guidelines for pharmacotherapy of Parkinson’s Disease
Abstract Parkinson’s Disease (PD) is one of the most frequent disorders of the central nervous system (CNS). PD is an age-related disease in that morbidity increases with age. The main symptoms of it are motor symptoms like bradykinesia, rigidity and resting tremor. These symptoms diminish the comfort of the patient’s life and may lead to immobility. Hence, rapid diagnosis and start of treatment are very important. The pharmacotherapy of PD is difficult. PD involves an imbalance between the dopaminergic and cholinergic systems. Therefore, the mechanisms of action of currently available drugs are highly connected with the pathology of PD, and follow dopaminergic or anticholinergic control strategies. However, long-term use of many PD medications comes with serious side effects. Therefore, the search for new, more effective drugs involving different strategies to that current and having different targets is still on-going.
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来源期刊
Current Issues in Pharmacy and Medical Sciences
Current Issues in Pharmacy and Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
0.80
自引率
0.00%
发文量
28
审稿时长
16 weeks
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