硫萝卜素对新生儿缺氧缺血性脑病大鼠脑葡萄糖摄取的影响

European Pharmaceutical Journal Pub Date : 2021-01-01 DOI:10.2478/afpuc-2021-0013

S. Kapoor, D. Kala, J. Svoboda, Z. Brnoliaková, J. Otáhal

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引用次数: 1

摘要

摘要新生儿缺氧缺血性损伤（HII）是新生儿发病和死亡的主要原因之一。它具有长期后果，代表着一种社会经济负担。这是当前新生儿医学的一个紧迫问题。本初步研究的目的是评估莱菔硫素在大鼠实验性围产期HII后急性、亚急性和亚慢性时间间隔对以18F-氟脱氧葡萄糖（18F-FDG）活性表达的脑葡萄糖摄取的可能影响。损伤后5周，在海马体中观察到显著的保护作用，表现为测量的18F-FDG活性的半球间比率正常化。总之，18F-FDG的正电子发射断层扫描（PET）揭示了SFN对HII后亚慢性期葡萄糖代谢的保护作用。有必要对新生大鼠的新生儿HII进行进一步的研究。

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The Effect of Sulphoraphane on Brain Glucose Uptake during Neonatal Hypoxic-Ischemic Encephalopathy in Newborn Rats

Abstract Neonatal hypoxic-ischemic insult (HII) is one of the leading causes of morbidity and mortality in newborns. It has long-term consequences and represents a socioeconomic burden. It is an urgent issue in current neonatology. The aim of the present pilot study was to evaluate the possible effect of sulforaphane on brain glucose uptake expressed as 18F-fluorodeoxyglucose (18F-FDG) activity at the acute, subacute, and subchronic time intervals after the experimental perinatal HII in rats. Significant protection has been observed in the hippocampus 5 weeks after the insult as represented by normalisations of interhemispheric ratio of measured 18F-FDG activity. In conclusion, positron emission tomography (PET) with 18F-FDG revealed a protective effect of SFN on glucose metabolism in the subchronic phase after HII. Further research within the field of neonatal HII in newborn rats will be necessary.

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.