化学反应生物谱在溶剂对C-C交联过程总毒性影响分析中的应用

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Doklady Chemistry Pub Date : 2022-11-03 DOI:10.1134/S0012500822600080

K. S. Egorova, A. S. Galushko, L. U. Dzhemileva, V. A. D’yakonov, V. P. Ananikov

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引用次数: 0

摘要

在这项工作中，我们采用了最近提出的生物概况和生物因子的概念，以芳基卤化物和苯硼酸合成1,1'-联苯为例，研究了化学反应中溶剂对“整体细胞毒性”的贡献。分析了两种标准溶剂(乙醇和n -甲基吡咯烷酮)和四种离子液体(1-乙基-3-甲基咪唑二(三氟甲基磺酰基)亚胺、1-乙基-3-甲基咪唑四氟硼酸盐、1-丁基-3-甲基咪唑二(三氟甲基磺酰基)亚胺和胆碱二(三氟甲基磺酰基)亚胺)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Application of Bio-Profiles of Chemical Reactions for Analysis of Solvent Impact on Overall Toxicity of C–C Cross-Coupling Process

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Application of Bio-Profiles of Chemical Reactions for Analysis of Solvent Impact on Overall Toxicity of C–C Cross-Coupling Process

In this work, we used a recently proposed concept of bio-Profiles and bio-Factors for studying the solvent contribution into the “overall cytotoxicity” of chemical reactions by the example of synthesis of 1,1'-biphenyl from aryl halide and phenylboronic acid. Two standard solvents (ethanol and N-methylpyrrolidone) and four ionic liquids (1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, and cholinium bis(trifluoromethylsulfonyl)imide) were analyzed.

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来源期刊

Doklady Chemistry 化学-化学综合

CiteScore

1.20

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.