基于烯丙基溴支架小分子的寡核苷酸纳米组装体

IF 4.703 3区材料科学

Nanoscale Research Letters Pub Date : 2023-06-03 DOI:10.1186/s11671-023-03846-0

Sk Jahir Abbas, Sabina Yesmin, Fangfang Xia, Sk Imran Ali, Zeyu Xiao, Weihong Tan

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引用次数: 0

摘要

小分子寡核苷酸纳米组件的开发在生物医学领域显示出巨大的应用潜力。然而，带负电荷的寡核苷酸与卤化小分子的相互作用是一个科学挑战。在这里，我们引入了一种独特的烯丙基溴卤化支架，它与寡核苷酸的腺嘌呤核碱基表现出特定的相互作用，从而导致自组装纳米结构的形成。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Oligonucleotide nanoassemblies with allyl bromide scaffold-based small molecules

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Oligonucleotide nanoassemblies with allyl bromide scaffold-based small molecules

The development of oligonucleotide nanoassemblies with small molecules has shown great potential in bio-medical applications. However, the interaction of negatively charged oligonucleotides with halogenated small molecules represents a scientific challenge. Here, we introduced a distinct allyl bromide halogenated scaffold, which exhibits specific interaction with adenine nucleic bases of the oligonucleotides, thus leading to the formation of self-assembled nanostructures.

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来源期刊

Nanoscale Research Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

15.00

自引率

0.00%

发文量

110

审稿时长

2.5 months

期刊介绍： Nanoscale Research Letters (NRL) provides an interdisciplinary forum for communication of scientific and technological advances in the creation and use of objects at the nanometer scale. NRL is the first nanotechnology journal from a major publisher to be published with Open Access.