{"title":"MnII和FeII大环配合物的Ct-DNA结合及抗菌研究","authors":"Anuj Kumar, Vinod Kumar Vashistha, Dipak Kumar Das, Ram K. Gupta, Ghulam Yasin","doi":"10.1007/s10847-022-01150-5","DOIUrl":null,"url":null,"abstract":"<div><p>The designing of efficient macrocyclic complexes for the alteration in nucleic acids and understanding is still in debate. Herein, to study the deoxyribonucleic acid (DNA) interaction with MN<sub>5</sub>-complexes, two macrocyclic complexes, A (Mn<sup>II</sup>) and B (Fe<sup>II</sup>), have been synthesized and characterized using multiple analytical techniques. The electronic absorption, fluorescence, and electrochemical methods were utilized to examine the binding ability of both complexes with calf thymus-DNA (ct-DNA). The spectral results were found to be in good agreement with the interaction of both complexes with ct-DNA, as also supported by the remarkable decrease in both anodic peak current (<i>i</i><sub>pa</sub>) and cathodic peak current (<i>i</i><sub>pc</sub>) during cyclic voltammetric analysis in the presence of ct-DNA. The spectral investigations clearly indicated the higher binding affinity of complex A as compared to complex B towards ct-DNA. Additionally, both complexes were also found to be potential antibacterial agents.</p></div>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 7-8","pages":"683 - 692"},"PeriodicalIF":1.7000,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-022-01150-5.pdf","citationCount":"2","resultStr":"{\"title\":\"Ct-DNA binding and antimicrobial studies of MnII and FeII macrocyclic complexes\",\"authors\":\"Anuj Kumar, Vinod Kumar Vashistha, Dipak Kumar Das, Ram K. Gupta, Ghulam Yasin\",\"doi\":\"10.1007/s10847-022-01150-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The designing of efficient macrocyclic complexes for the alteration in nucleic acids and understanding is still in debate. Herein, to study the deoxyribonucleic acid (DNA) interaction with MN<sub>5</sub>-complexes, two macrocyclic complexes, A (Mn<sup>II</sup>) and B (Fe<sup>II</sup>), have been synthesized and characterized using multiple analytical techniques. The electronic absorption, fluorescence, and electrochemical methods were utilized to examine the binding ability of both complexes with calf thymus-DNA (ct-DNA). The spectral results were found to be in good agreement with the interaction of both complexes with ct-DNA, as also supported by the remarkable decrease in both anodic peak current (<i>i</i><sub>pa</sub>) and cathodic peak current (<i>i</i><sub>pc</sub>) during cyclic voltammetric analysis in the presence of ct-DNA. The spectral investigations clearly indicated the higher binding affinity of complex A as compared to complex B towards ct-DNA. Additionally, both complexes were also found to be potential antibacterial agents.</p></div>\",\"PeriodicalId\":54324,\"journal\":{\"name\":\"Journal of Inclusion Phenomena and Macrocyclic Chemistry\",\"volume\":\"102 7-8\",\"pages\":\"683 - 692\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2022-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s10847-022-01150-5.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Inclusion Phenomena and Macrocyclic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10847-022-01150-5\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10847-022-01150-5","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Ct-DNA binding and antimicrobial studies of MnII and FeII macrocyclic complexes
The designing of efficient macrocyclic complexes for the alteration in nucleic acids and understanding is still in debate. Herein, to study the deoxyribonucleic acid (DNA) interaction with MN5-complexes, two macrocyclic complexes, A (MnII) and B (FeII), have been synthesized and characterized using multiple analytical techniques. The electronic absorption, fluorescence, and electrochemical methods were utilized to examine the binding ability of both complexes with calf thymus-DNA (ct-DNA). The spectral results were found to be in good agreement with the interaction of both complexes with ct-DNA, as also supported by the remarkable decrease in both anodic peak current (ipa) and cathodic peak current (ipc) during cyclic voltammetric analysis in the presence of ct-DNA. The spectral investigations clearly indicated the higher binding affinity of complex A as compared to complex B towards ct-DNA. Additionally, both complexes were also found to be potential antibacterial agents.
期刊介绍：
The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites.
The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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