研究微生物-宿主相互作用的新方法方法(NAMs)

IF 6.1 Q1 TOXICOLOGY

Current Opinion in Toxicology Pub Date : 2023-09-01 DOI:10.1016/j.cotox.2023.100406

Chen Liu , Jing Jin , Ivonne M.C.M. Rietjens

{"title":"研究微生物-宿主相互作用的新方法方法(NAMs)","authors":"Chen Liu , Jing Jin , Ivonne M.C.M. Rietjens","doi":"10.1016/j.cotox.2023.100406","DOIUrl":null,"url":null,"abstract":"<div>Gut microbiota plays an important role in host health and disease. They metabolize food-born chemicals, nutrients, drugs and other xenobiotics, while these chemicals and their metabolites can also modulate the gut microbiota. The present review provided an overview of the state-of-the-art in the application of in vitro and in silico based new approach methodologies (NAMs) to study these microbiome–host interactions in a non-invasive way and without the need for the use of animal or human studies.</div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"35 ","pages":"Article 100406"},"PeriodicalIF":6.1000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New approach methodologies (NAMs) to study microbiome–host interactions\",\"authors\":\"Chen Liu , Jing Jin , Ivonne M.C.M. Rietjens\",\"doi\":\"10.1016/j.cotox.2023.100406\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>Gut microbiota plays an important role in host health and disease. They metabolize food-born chemicals, nutrients, drugs and other xenobiotics, while these chemicals and their metabolites can also modulate the gut microbiota. The present review provided an overview of the state-of-the-art in the application of in vitro and in silico based new approach methodologies (NAMs) to study these microbiome–host interactions in a non-invasive way and without the need for the use of animal or human studies.</div>\",\"PeriodicalId\":37736,\"journal\":{\"name\":\"Current Opinion in Toxicology\",\"volume\":\"35 \",\"pages\":\"Article 100406\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468202023000219\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202023000219","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

肠道菌群在宿主健康和疾病中起着重要作用。它们代谢食物中的化学物质、营养物质、药物和其他外来生物，而这些化学物质及其代谢物也可以调节肠道微生物群。本综述概述了体外和基于芯片的新方法(NAMs)的最新应用，以非侵入性的方式研究这些微生物组-宿主相互作用，而无需使用动物或人体研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

New approach methodologies (NAMs) to study microbiome–host interactions

Gut microbiota plays an important role in host health and disease. They metabolize food-born chemicals, nutrients, drugs and other xenobiotics, while these chemicals and their metabolites can also modulate the gut microbiota. The present review provided an overview of the state-of-the-art in the application of in vitro and in silico based new approach methodologies (NAMs) to study these microbiome–host interactions in a non-invasive way and without the need for the use of animal or human studies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Opinion in Toxicology Pharmacology, Toxicology and Pharmaceutics-Toxicology

CiteScore

10.40

自引率

0.00%

发文量

期刊介绍： The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.