核医学成像在心肌淀粉样变诊断中的应用

中华核医学与分子影像杂志 Pub Date : 2019-12-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2019.12.013

Jingyun Ren, Shan He, Z. Tian, Peng Liu, L. Huo, Fang Li, Shuyang Zhang

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引用次数: 0

摘要

淀粉样变性是一种由淀粉样蛋白异常沉积引起的疾病，涉及心肌的淀粉样变性主要类型为轻链淀粉样变性（AL）和转甲状腺素相关淀粉样变（ATTR）。不同类型的心肌淀粉样变性有不同的预后和治疗方法。因此，早期诊断和分类尤为重要。核医学成像可以无创地诊断和分类心肌淀粉样变性。骨显像放射性示踪剂对ATTR的诊断具有较高的敏感性和特异性，对预后有一定的价值。交感神经支配成像示踪剂可以检测心脏交感神经支配，这可能比骨闪烁扫描更早显示淀粉样变性的心肌受累。淀粉样蛋白特异性显像剂最早用于诊断神经系统淀粉样变性，在心肌淀粉样变性的初步研究中也取得了良好的结果，AL的诊断特异性略好于ATTR。本文就核医学成像在心肌淀粉样变性中的应用作一综述。关键词：淀粉样变性；心肌；放射性核素成像；正电子发射断层扫描；3-碘苄基胍；淀粉样蛋白；趋势

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Application of nuclear medical imaging in the diagnosis of myocardial amyloidosis

Amyloidosis is a disease caused by abnormal deposition of amyloid protein, and the main types of amyloidosis involving myocardium are light chain amyloidosis (AL) and transthyretin-related amyloidosis (ATTR). Different types of myocardial amyloidosis have different prognosis and treatment methods. Therefore, early diagnosis and classification are particularly important. Nuclear medical imaging can diagnose and classify myocardial amyloidosis noninvasively. Radiotracers for bone scintigraphy has high sensitivity and specificity for the diagnosis of ATTR, and have certain value for prognosis. Sympathetic innervation imaging tracers can detect cardiac sympathetic innervation, which may show myocardial involvement of amyloidosis earlier than bone scintigraphy. Amyloid protein specific imaging agent, which was first used in the diagnosis of amyloidosis in nervous system, has also yielded good results from preliminary studies in myocardial amyloidosis, and the diagnostic specificity in AL is slightly better than that in ATTR. This review introduces the application of nuclear medical imaging in myocardial amyloidosis. Key words: Amyloidosis; Myocardium; Radionuclide imaging; Positron-emission tomography; 3-idobenzylguanidine; Amyloid; Trends

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.