ABC转运蛋白结构生物学领域扩展的Meta分析。

Q2 Agricultural and Biological Sciences
生物设计研究(英文) Pub Date : 2022-09-08 eCollection Date: 2022-01-01 DOI:10.34133/2022/9806979
Soomi Kim, Teena Bajaj, Cole Chabon, Eric Tablante, Tatyana Kulchinskaya, Tae Seok Moon, Ruchika Bajaj
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引用次数: 0

摘要

ABC转运蛋白是利用ATP水解为溶质转运提供动力的分子机器。在过去的几年里,ABC转运蛋白的结构生物学一直在爆炸式发展,这项研究探索了各种属性的时间表和趋势,如结构工具、分辨率、折叠、来源和群体领导者。这项研究还证明了哺乳动物表达系统的重要性、结构生物学工具的进步,以及世界各地团队领导者对这一显著进步领域的兴趣。该领域始于2002年,并于2016年蓬勃发展,新冠肺炎疫情对该领域来说真的很有成效。具体而言,该研究探索了PDB数据库中58种独特ABC转运蛋白的337种结构,其中P-糖蛋白具有最多的结构。大约62%的总结构是在3-4的分辨率下确定的 Å和53%的结构属于折叠IV型。随着该领域的不断进步,该领域正从原核来源转向真核来源,从X射线晶体学转向冷冻电子显微镜。简言之,这项研究独特地为ABC转运蛋白的结构生物学领域提供了实时数据的详细快照。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters.

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters.

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters.

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters.

ABC transporters are molecular machines which power the solute transport using ATP hydrolysis. The structural biology of ABC transporters has been exploding for the last few years, and this study explores timelines and trends for various attributes such as structural tools, resolution, fold, sources, and group leaders. This study also evidences the significance of mammalian expression systems, advancements in structural biology tools, and the developing interest of group leaders across the world in the remarkably progressing field. The field started in 2002 and bloomed in 2016, and COVID years were really productive to the field. Specifically, the study explores 337 structures of 58 unique ABC transporters deposited in the PDB database from which P-glycoprotein has the largest number of structures. Approximately, 62% of total structures are determined at the resolution of 3-4 Å and 53% of structures belong to fold IV type. With progressive advancements in the field, the field is shifting from prokaryotic to eukaryotic sources and X-ray crystallography to cryoelectron microscopy. In the nutshell, this study uniquely provides the detailed snapshot of the field of structural biology of ABC transporters with real-time data.

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CiteScore
3.90
自引率
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