ABC转运蛋白结构生物学领域扩展的Meta分析。

Q2 Agricultural and Biological Sciences
生物设计研究(英文) Pub Date : 2022-09-08 eCollection Date: 2022-01-01 DOI:10.34133/2022/9806979
Soomi Kim, Teena Bajaj, Cole Chabon, Eric Tablante, Tatyana Kulchinskaya, Tae Seok Moon, Ruchika Bajaj
{"title":"ABC转运蛋白结构生物学领域扩展的Meta分析。","authors":"Soomi Kim,&nbsp;Teena Bajaj,&nbsp;Cole Chabon,&nbsp;Eric Tablante,&nbsp;Tatyana Kulchinskaya,&nbsp;Tae Seok Moon,&nbsp;Ruchika Bajaj","doi":"10.34133/2022/9806979","DOIUrl":null,"url":null,"abstract":"<p><p>ABC transporters are molecular machines which power the solute transport using ATP hydrolysis. The structural biology of ABC transporters has been exploding for the last few years, and this study explores timelines and trends for various attributes such as structural tools, resolution, fold, sources, and group leaders. This study also evidences the significance of mammalian expression systems, advancements in structural biology tools, and the developing interest of group leaders across the world in the remarkably progressing field. The field started in 2002 and bloomed in 2016, and COVID years were really productive to the field. Specifically, the study explores 337 structures of 58 unique ABC transporters deposited in the PDB database from which P-glycoprotein has the largest number of structures. Approximately, 62% of total structures are determined at the resolution of 3-4 Å and 53% of structures belong to fold IV type. With progressive advancements in the field, the field is shifting from prokaryotic to eukaryotic sources and X-ray crystallography to cryoelectron microscopy. In the nutshell, this study uniquely provides the detailed snapshot of the field of structural biology of ABC transporters with real-time data.</p>","PeriodicalId":56832,"journal":{"name":"生物设计研究(英文)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521687/pdf/","citationCount":"0","resultStr":"{\"title\":\"Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters.\",\"authors\":\"Soomi Kim,&nbsp;Teena Bajaj,&nbsp;Cole Chabon,&nbsp;Eric Tablante,&nbsp;Tatyana Kulchinskaya,&nbsp;Tae Seok Moon,&nbsp;Ruchika Bajaj\",\"doi\":\"10.34133/2022/9806979\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>ABC transporters are molecular machines which power the solute transport using ATP hydrolysis. The structural biology of ABC transporters has been exploding for the last few years, and this study explores timelines and trends for various attributes such as structural tools, resolution, fold, sources, and group leaders. This study also evidences the significance of mammalian expression systems, advancements in structural biology tools, and the developing interest of group leaders across the world in the remarkably progressing field. The field started in 2002 and bloomed in 2016, and COVID years were really productive to the field. Specifically, the study explores 337 structures of 58 unique ABC transporters deposited in the PDB database from which P-glycoprotein has the largest number of structures. Approximately, 62% of total structures are determined at the resolution of 3-4 Å and 53% of structures belong to fold IV type. With progressive advancements in the field, the field is shifting from prokaryotic to eukaryotic sources and X-ray crystallography to cryoelectron microscopy. In the nutshell, this study uniquely provides the detailed snapshot of the field of structural biology of ABC transporters with real-time data.</p>\",\"PeriodicalId\":56832,\"journal\":{\"name\":\"生物设计研究(英文)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521687/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"生物设计研究(英文)\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://doi.org/10.34133/2022/9806979\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"生物设计研究(英文)","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.34133/2022/9806979","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0

摘要

ABC转运蛋白是利用ATP水解为溶质转运提供动力的分子机器。在过去的几年里,ABC转运蛋白的结构生物学一直在爆炸式发展,这项研究探索了各种属性的时间表和趋势,如结构工具、分辨率、折叠、来源和群体领导者。这项研究还证明了哺乳动物表达系统的重要性、结构生物学工具的进步,以及世界各地团队领导者对这一显著进步领域的兴趣。该领域始于2002年,并于2016年蓬勃发展,新冠肺炎疫情对该领域来说真的很有成效。具体而言,该研究探索了PDB数据库中58种独特ABC转运蛋白的337种结构,其中P-糖蛋白具有最多的结构。大约62%的总结构是在3-4的分辨率下确定的 Å和53%的结构属于折叠IV型。随着该领域的不断进步,该领域正从原核来源转向真核来源,从X射线晶体学转向冷冻电子显微镜。简言之,这项研究独特地为ABC转运蛋白的结构生物学领域提供了实时数据的详细快照。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters.

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters.

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters.

Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters.

ABC transporters are molecular machines which power the solute transport using ATP hydrolysis. The structural biology of ABC transporters has been exploding for the last few years, and this study explores timelines and trends for various attributes such as structural tools, resolution, fold, sources, and group leaders. This study also evidences the significance of mammalian expression systems, advancements in structural biology tools, and the developing interest of group leaders across the world in the remarkably progressing field. The field started in 2002 and bloomed in 2016, and COVID years were really productive to the field. Specifically, the study explores 337 structures of 58 unique ABC transporters deposited in the PDB database from which P-glycoprotein has the largest number of structures. Approximately, 62% of total structures are determined at the resolution of 3-4 Å and 53% of structures belong to fold IV type. With progressive advancements in the field, the field is shifting from prokaryotic to eukaryotic sources and X-ray crystallography to cryoelectron microscopy. In the nutshell, this study uniquely provides the detailed snapshot of the field of structural biology of ABC transporters with real-time data.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信