Francesco Giangreco, Elisabetta Iacopi, Vittorio Malquori, Letizia Pieruzzi, Chiara Goretti, Alberto Piaggesi
{"title":"在血液中，我们相信：贫血是糖尿病足患者的一个负面愈合预后因素。","authors":"Francesco Giangreco, Elisabetta Iacopi, Vittorio Malquori, Letizia Pieruzzi, Chiara Goretti, Alberto Piaggesi","doi":"10.1007/s00592-023-02188-8","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>Anemia has been associated with severity of diabetic foot (DF) disease. Our study aimed to evaluate whether the presence of anemia could decrease the healing chances in DF.</p><h3>Methods</h3><p>We retrospectively analyzed all patients admitted in our department in 2021 for DF, dividing them according to presence (Group A) or absence (Group B) of anemia. Groups were compared for clinical and demographic characteristics, procedures and outcomes: healing rate (HR) at 6 months, healing time (HT) and recurrence rate (RR) at 12 months.</p><h3>Results</h3><p>We sorted out data from 196 consecutive patients: 114 (58%) in Group A and 82 (42%) in B. Group A had a higher male prevalence and a longer duration of disease. Group A showed lower hemoglobin concentration (10.3 ± 1.3 g/dL vs 13.1 ± 1.4 g/dL, <i>p</i> < 0.002) and red blood cells count (3.4 ± 0.5 × 10<sup>6</sup>/mL vs 4.8 ± 0.6 × 10<sup>6</sup>/mL, <i>p</i> = 0.004). Group A presented a lower HR (55.2% vs 76.8%, <i>p</i> = 0.0028), no differences in HT and a higher RR (23.6% vs 17.1%, <i>p</i> < 0.02). Cox’s logistic regression on healing confirmed the negative impact of anemia: hazard ratio 2.8 (CI 95% 1.4–5.4, <i>p</i> = 0.0037).</p><h3>Conclusions</h3><p>Anemia is frequent in DF and associates to a reduction in healing chances and an increase in recurrences representing an independent predictor of healing failure.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 2","pages":"245 - 251"},"PeriodicalIF":3.1000,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In blood we trust: anemia as a negative healing prognostic factor in diabetic foot patients\",\"authors\":\"Francesco Giangreco, Elisabetta Iacopi, Vittorio Malquori, Letizia Pieruzzi, Chiara Goretti, Alberto Piaggesi\",\"doi\":\"10.1007/s00592-023-02188-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><p>Anemia has been associated with severity of diabetic foot (DF) disease. Our study aimed to evaluate whether the presence of anemia could decrease the healing chances in DF.</p><h3>Methods</h3><p>We retrospectively analyzed all patients admitted in our department in 2021 for DF, dividing them according to presence (Group A) or absence (Group B) of anemia. Groups were compared for clinical and demographic characteristics, procedures and outcomes: healing rate (HR) at 6 months, healing time (HT) and recurrence rate (RR) at 12 months.</p><h3>Results</h3><p>We sorted out data from 196 consecutive patients: 114 (58%) in Group A and 82 (42%) in B. Group A had a higher male prevalence and a longer duration of disease. Group A showed lower hemoglobin concentration (10.3 ± 1.3 g/dL vs 13.1 ± 1.4 g/dL, <i>p</i> < 0.002) and red blood cells count (3.4 ± 0.5 × 10<sup>6</sup>/mL vs 4.8 ± 0.6 × 10<sup>6</sup>/mL, <i>p</i> = 0.004). Group A presented a lower HR (55.2% vs 76.8%, <i>p</i> = 0.0028), no differences in HT and a higher RR (23.6% vs 17.1%, <i>p</i> < 0.02). Cox’s logistic regression on healing confirmed the negative impact of anemia: hazard ratio 2.8 (CI 95% 1.4–5.4, <i>p</i> = 0.0037).</p><h3>Conclusions</h3><p>Anemia is frequent in DF and associates to a reduction in healing chances and an increase in recurrences representing an independent predictor of healing failure.</p></div>\",\"PeriodicalId\":6921,\"journal\":{\"name\":\"Acta Diabetologica\",\"volume\":\"61 2\",\"pages\":\"245 - 251\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2023-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Diabetologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00592-023-02188-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Diabetologica","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00592-023-02188-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
In blood we trust: anemia as a negative healing prognostic factor in diabetic foot patients
Aim
Anemia has been associated with severity of diabetic foot (DF) disease. Our study aimed to evaluate whether the presence of anemia could decrease the healing chances in DF.
Methods
We retrospectively analyzed all patients admitted in our department in 2021 for DF, dividing them according to presence (Group A) or absence (Group B) of anemia. Groups were compared for clinical and demographic characteristics, procedures and outcomes: healing rate (HR) at 6 months, healing time (HT) and recurrence rate (RR) at 12 months.
Results
We sorted out data from 196 consecutive patients: 114 (58%) in Group A and 82 (42%) in B. Group A had a higher male prevalence and a longer duration of disease. Group A showed lower hemoglobin concentration (10.3 ± 1.3 g/dL vs 13.1 ± 1.4 g/dL, p < 0.002) and red blood cells count (3.4 ± 0.5 × 106/mL vs 4.8 ± 0.6 × 106/mL, p = 0.004). Group A presented a lower HR (55.2% vs 76.8%, p = 0.0028), no differences in HT and a higher RR (23.6% vs 17.1%, p < 0.02). Cox’s logistic regression on healing confirmed the negative impact of anemia: hazard ratio 2.8 (CI 95% 1.4–5.4, p = 0.0037).
Conclusions
Anemia is frequent in DF and associates to a reduction in healing chances and an increase in recurrences representing an independent predictor of healing failure.
期刊介绍：
Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.
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