2型糖尿病增加了成人外伤性脊髓损伤患者患严重和危及生命疾病的风险。

Michelle A. Meade PhD , Zhe Yin MS , Paul Lin MS , Neil Kamdar MA , Gianna Rodriguez MD , Michael McKee MD, MPH , Mark D. Peterson PhD, MS
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引用次数: 0

摘要

目的:比较伴有和不伴有2型糖尿病(T2D)的成人创伤性脊髓损伤(TSCI)的严重和危及生命的疾病的发生率和调整后的危险性。参与者和方法:从2022年9月1日至2023年2月2日,在私人保险受益人中进行了一项回顾性纵向队列研究,如果他们有国际疾病分类,第9版或第10版,TSCI临床改良诊断代码(n=9081)。在入组5年时,对严重和危及生命的疾病以及更常见的继发和长期健康状况的发病率估计进行了比较。生存模型用于量化严重和危及生命的疾病的未调整和调整的风险比。结果:与患有TSCI的非糖尿病成年人相比,患有TSCI和T2D的成年人在所有评估的疾病中的发病率都更高。完全调整的生存模型报告称,患有TSCI和T2D的成年人在大多数严重和危及生命的情况下都有更大的风险,包括败血症(风险比[HR]:1.65)、心肌梗死(HR:1.63)、骨髓炎(HR:1.9),以及中风或短暂性脑缺血发作(HR:1.59)。TSCI和T2D患者的合并症和继发性疾病发生率更高,如压疮、尿路感染和抑郁症,即使在控制了社会人口和合并症的情况下也是如此。结论:与患有TSCI的非糖尿病成年人相比,患有TSCI和T2D的成年人患严重和危及生命的疾病的发生率和风险明显更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Type 2 Diabetes Increases the Risk of Serious and Life-Threatening Conditions Among Adults With Traumatic Spinal Cord Injury

Type 2 Diabetes Increases the Risk of Serious and Life-Threatening Conditions Among Adults With Traumatic Spinal Cord Injury

Objective

To compare the incidence of and adjusted hazards for serious and life-threatening morbidities among adults with traumatic spinal cord injury (TSCI) with and without type 2 diabetes (T2D).

Participants and Methods

A retrospective longitudinal cohort study was conducted from September 1, 2022 to February 2, 2023, among privately insured beneficiaries if they had an International Classification of Diseases, 9th Revision or 10th Revision, Clinical Modification diagnostic code for TSCI (n=9081). Incidence estimates of serious and life-threatening morbidities, and more common secondary and long-term health conditions, were compared at 5 years of enrollment. Survival models were used to quantify unadjusted and adjusted hazard ratios for serious and life-threatening morbidities.

Results

Adults living with TSCI and T2D had a higher incidence of all of the morbidities assessed as compared with nondiabetic adults with TSCI. Fully adjusted survival models reported that adults with TSCI and T2D had a greater hazard for most of the serious and life-threatening conditions assessed, including sepsis (hazard ratio [HR]: 1.65), myocardial infarction (HR: 1.63), osteomyelitis (HR: 1.9), and stroke or transient ischemic attack (HR: 1.59). Rates for comorbid and secondary conditions were higher for individuals with TSCI and T2D, such as pressure sores, urinary tract infections, and depression, even after controlling for sociodemographic and comorbid conditions.

Conclusion

Adults living with TSCI and T2D have a significantly higher incidence of and risk of developing serious and life-threatening morbidities as compared with nondiabetic adults with TSCI.

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来源期刊
Mayo Clinic proceedings. Innovations, quality & outcomes
Mayo Clinic proceedings. Innovations, quality & outcomes Surgery, Critical Care and Intensive Care Medicine, Public Health and Health Policy
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