2型糖尿病、氧化应激和炎症:研究它们之间的联系。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2019-06-15 eCollection Date: 2019-01-01
Oluwafemi Omoniyi Oguntibeju
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引用次数: 0

摘要

糖尿病已被公认为四大非传染性疾病之一,需要全球所有主要股东紧急关注,以解决其流行率和相关并发症。它被认为是全球十大死亡原因,全球约有160万人死亡,并被视为全球因高血糖和高血糖诱导的氧化应激和炎症而过早死亡的第三高风险因素。高血糖、高血糖诱导的氧化应激、炎症与2型糖尿病的发展和进展之间有着密切的联系。各种报告表明,慢性低度炎症与患2型糖尿病的风险有关,亚临床炎症会导致胰岛素抵抗,并与包括高血糖在内的代谢综合征的特征有关。氧化应激刺激炎症介质的产生,而炎症反过来又增强了活性氧的产生。糖尿病、氧化应激和炎症之间的相互作用是编写本综述的主要动机。基于先前的研究,该综述考察了糖尿病、氧化应激和炎症之间的相互作用、促进糖尿病患病率的因素、高血糖诱导的氧化应激的机制,特别关注2型糖尿病和选定的糖尿病并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.

Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.

Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.

Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.

Diabetes mellitus has been recognised as one of the four major non-communicable diseases that demands urgent attention from all key shareholders globally in an effort to address its prevalence and associated complications. It is considered as a top 10 cause of death globally, killing about 1.6 million people worldwide and is seen as the third highest risk factor for worldwide premature mortality due to hyperglycaemia and hyperglycaemic-induced oxidative stress and inflammation. There is a strong link between hyperglycaemia, hyperglycaemic-induced oxidative stress, inflammation and the development and progression of type 2 diabetes mellitus. Various reports have shown that chronic low-grade inflammation is associated with the risk of developing type 2 diabetes and that sub-clinical inflammation contributes to insulin resistance and is linked to the characteristics of metabolic syndrome which include hyperglycaemia. Oxidative stress stimulates the generation of inflammatory mediators and inflammation in turn enhances the production of reactive oxygen species. This interaction between diabetes, oxidative stress and inflammation is the primary motivation for the compilation of this review. Based on previous studies, the review examines the interaction between diabetes, oxidative stress and inflammation, factors promoting prevalence of diabetes mellitus, mechanisms involved in hyperglycaemia-induced oxidative stress with particular focus on type 2 diabetes and selected diabetic complications.

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