癌症作为一种发展中的疾病已经过时。

IF 28.4 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2024-01-24 Epub Date: 2023-10-13 DOI:10.1146/annurev-pathmechdis-031621-025610

Ben Z Stanger, Geoffrey M Wahl

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引用次数: 0

摘要

Rudolf Virchow首次假设肿瘤是由调节胚胎发育的同一定律引起的，在这160年里，科学家们已经认识到癌症和胚胎所使用的分子和细胞程序之间的惊人重叠。癌症生物学和分子技术的进展进一步突出了致癌作用和胚胎发生之间的相似性，其中细胞生长、分化、运动和细胞间串扰是由共同的驱动因素和调节网络介导的。这篇综述强调了癌症生物学和发育生物学之间的许多联系，以更深入地了解组织的发育史如何既能促进又能限制癌症细胞的进化。《病理学年度评论：疾病机制》第19卷预计最终在线出版日期为2024年1月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

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Cancer as a Disease of Development Gone Awry.

In the 160 years since Rudolf Virchow first postulated that neoplasia arises by the same law that regulates embryonic development, scientists have come to recognize the striking overlap between the molecular and cellular programs used by cancers and embryos. Advances in cancer biology and molecular techniques have further highlighted the similarities between carcinogenesis and embryogenesis, where cellular growth, differentiation, motility, and intercellular cross talk are mediated by common drivers and regulatory networks. This review highlights the many connections linking cancer biology and developmental biology to provide a deeper understanding of how a tissue's developmental history may both enable and constrain cancer cell evolution.

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.