早期炎症性肠病的遗传缺陷。

IF 2.6 4区医学 Q2 RHEUMATOLOGY

Rheumatic Disease Clinics of North America Pub Date : 2023-08-12 DOI:10.1016/j.rdc.2023.06.006

Atiye Olcay Bilgic Dagci MD , Kelly Colleen Cushing MD

引用次数: 0

摘要

炎症性肠病（IBD）是以慢性胃肠道炎症为特征的一系列疾病。与成人发病相比，驱动IBD发病机制的单基因突变在早发性疾病中更具代表性。在单基因IBD中失调宿主免疫反应的致病基因影响先天免疫系统（即肠道屏障、吞噬细胞）和适应性免疫系统（如T细胞、B细胞）。先进的基因组和靶向功能测试可以改善临床决策，并为这一重要患者群体提供更多的精准医学方法机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Genetic Defects in Early-Onset Inflammatory Bowel Disease

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来源期刊

Rheumatic Disease Clinics of North America 医学-风湿病学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Rheumatic Disease Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Each issue (February, May, August, and November) focuses on a single topic in rheumatology and is presented under the direction of an experienced editor. Topics include osteoarthritis, rheumatoid arthritis, crystal diseases, MSK exam, disorders of the bone, immunodeficiency states, lupus, neuromuscular disease, pain disorders, scleroderma, vasculitis, pediatrics, therapeutics, treatment guidelines, and treatment modalities.