Yang Guo, Xia Dou, Xiao-Fan Chen, Cong Huang, Ying-Jie Zheng, Bo Yu
{"title":"金黄色葡萄球菌鼻腔定植与多部位湿疹的关系。","authors":"Yang Guo, Xia Dou, Xiao-Fan Chen, Cong Huang, Ying-Jie Zheng, Bo Yu","doi":"10.4168/aair.2023.15.5.659","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong><i>Staphylococcus aureus</i> is the critical pathogenic bacterium of eczema. The relationship between nasal colonization by <i>S. aureus</i> and eczema has not been well studied. We aimed to evaluate the associations between nasal colonization by <i>S. aureus</i> and eczema of multiple body sites, including persistent and ever-reported eczema. We further examined the associations between eczema and different subtypes of <i>S. aureus</i>, that is, methicillin-resistant <i>S. aureus</i> (MRSA) and methicillin-sensitive <i>S. aureus</i> (MSSA).</p><p><strong>Methods: </strong>The real-world data from the US National Health and Nutrition Examination Survey were used. The associations were calculated using survey-weighted multinomial logistic regression models and further calculated in subgroups stratified by demographic factors.</p><p><strong>Results: </strong>In total, 2,941 adults were included. The prevalence rate of <i>S. aureus</i> nasal carriage was significantly higher in adults with persistent hand eczema (51.0%) than in those with ever-reported hand eczema (23.3%) and never eczema (26.9%). <i>S. aureus</i> nasal colonization was associated with an approximately two-fold increased risk of persistent hand eczema (odds ratios ranges in different models: 2.86-3.06) without significant heterogeneity in the association by demographic factors. No significant associations between <i>S. aureus</i> nasal colonization and persistent eczema of other body sites or ever-reported eczema of multiple body sites (including hands) were observed. Furthermore, similar significant association between nasal colonization of MSSA and persistent hand eczema was seen; the association was much stronger (odds ratios ranges in different models: 4.64-6.54) for MRSA, although with borderline significant.</p><p><strong>Conclusions: </strong>Nasal colonization of <i>S. aureu</i>s was associated with increased risk of persistent hand eczema. Our findings imply that preventive measures targeting <i>S. aureus</i> for the anterior nares should be considered in preventing and treating eczema.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 5","pages":"659-672"},"PeriodicalIF":4.1000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/8e/aair-15-659.PMC10570784.pdf","citationCount":"0","resultStr":"{\"title\":\"Association Between Nasal Colonization of <i>Staphylococcus aureus</i> and Eczema of Multiple Body Sites.\",\"authors\":\"Yang Guo, Xia Dou, Xiao-Fan Chen, Cong Huang, Ying-Jie Zheng, Bo Yu\",\"doi\":\"10.4168/aair.2023.15.5.659\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong><i>Staphylococcus aureus</i> is the critical pathogenic bacterium of eczema. The relationship between nasal colonization by <i>S. aureus</i> and eczema has not been well studied. We aimed to evaluate the associations between nasal colonization by <i>S. aureus</i> and eczema of multiple body sites, including persistent and ever-reported eczema. We further examined the associations between eczema and different subtypes of <i>S. aureus</i>, that is, methicillin-resistant <i>S. aureus</i> (MRSA) and methicillin-sensitive <i>S. aureus</i> (MSSA).</p><p><strong>Methods: </strong>The real-world data from the US National Health and Nutrition Examination Survey were used. The associations were calculated using survey-weighted multinomial logistic regression models and further calculated in subgroups stratified by demographic factors.</p><p><strong>Results: </strong>In total, 2,941 adults were included. The prevalence rate of <i>S. aureus</i> nasal carriage was significantly higher in adults with persistent hand eczema (51.0%) than in those with ever-reported hand eczema (23.3%) and never eczema (26.9%). <i>S. aureus</i> nasal colonization was associated with an approximately two-fold increased risk of persistent hand eczema (odds ratios ranges in different models: 2.86-3.06) without significant heterogeneity in the association by demographic factors. No significant associations between <i>S. aureus</i> nasal colonization and persistent eczema of other body sites or ever-reported eczema of multiple body sites (including hands) were observed. Furthermore, similar significant association between nasal colonization of MSSA and persistent hand eczema was seen; the association was much stronger (odds ratios ranges in different models: 4.64-6.54) for MRSA, although with borderline significant.</p><p><strong>Conclusions: </strong>Nasal colonization of <i>S. aureu</i>s was associated with increased risk of persistent hand eczema. Our findings imply that preventive measures targeting <i>S. aureus</i> for the anterior nares should be considered in preventing and treating eczema.</p>\",\"PeriodicalId\":7547,\"journal\":{\"name\":\"Allergy, Asthma & Immunology Research\",\"volume\":\"15 5\",\"pages\":\"659-672\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/8e/aair-15-659.PMC10570784.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Allergy, Asthma & Immunology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4168/aair.2023.15.5.659\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergy, Asthma & Immunology Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4168/aair.2023.15.5.659","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}
Association Between Nasal Colonization of Staphylococcus aureus and Eczema of Multiple Body Sites.
Purpose: Staphylococcus aureus is the critical pathogenic bacterium of eczema. The relationship between nasal colonization by S. aureus and eczema has not been well studied. We aimed to evaluate the associations between nasal colonization by S. aureus and eczema of multiple body sites, including persistent and ever-reported eczema. We further examined the associations between eczema and different subtypes of S. aureus, that is, methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA).
Methods: The real-world data from the US National Health and Nutrition Examination Survey were used. The associations were calculated using survey-weighted multinomial logistic regression models and further calculated in subgroups stratified by demographic factors.
Results: In total, 2,941 adults were included. The prevalence rate of S. aureus nasal carriage was significantly higher in adults with persistent hand eczema (51.0%) than in those with ever-reported hand eczema (23.3%) and never eczema (26.9%). S. aureus nasal colonization was associated with an approximately two-fold increased risk of persistent hand eczema (odds ratios ranges in different models: 2.86-3.06) without significant heterogeneity in the association by demographic factors. No significant associations between S. aureus nasal colonization and persistent eczema of other body sites or ever-reported eczema of multiple body sites (including hands) were observed. Furthermore, similar significant association between nasal colonization of MSSA and persistent hand eczema was seen; the association was much stronger (odds ratios ranges in different models: 4.64-6.54) for MRSA, although with borderline significant.
Conclusions: Nasal colonization of S. aureus was associated with increased risk of persistent hand eczema. Our findings imply that preventive measures targeting S. aureus for the anterior nares should be considered in preventing and treating eczema.
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The journal features cutting-edge original research, brief communications, and state-of-the-art reviews in the specialties of allergy, asthma, and immunology, including clinical and experimental studies and instructive case reports. Contemporary reviews summarize information on topics for researchers and physicians in the fields of allergy and immunology. As of January 2017, AAIR do not accept case reports. However, if it is a clinically important case, authors can submit it in the form of letter to the Editor. Editorials and letters to the Editor explore controversial issues and encourage further discussion among physicians dealing with allergy, immunology, pediatric respirology, and related medical fields. AAIR also features topics in practice and management and recent advances in equipment and techniques for clinicians concerned with clinical manifestations of allergies and pediatric respiratory diseases.
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