驱动严重急性呼吸系统综合征冠状病毒2型变异株进化和全球传播的免疫学和病毒学因素概述。

IF 2.7 4区医学 Q3 IMMUNOLOGY

Indian Journal of Medical Research Pub Date : 2023-09-01 DOI:10.4103/ijmr.ijmr_2591_22

Ranjan Ramasamy

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引用次数: 1

摘要

2019年12月首次发现的传染性极强的正链RNA病毒SARS-CoV-2产生了多种基因变异，在2019冠状病毒病（新冠肺炎）大流行期间，这些变异在全球范围内迅速连续传播。在大流行的早期阶段，选择了严重急性呼吸系统综合征冠状病毒2型的基因变化，以增强传染性、复制和传播。最近，在广泛感染和接种疫苗后，已经开始选择逃避抗原特异性适应性免疫的严重急性呼吸系统综合征冠状病毒2型变体。本文概述了重要的严重急性呼吸系统综合征冠状病毒2型变异谱系的起源和全球传播的分子免疫学和病毒学因素。

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Overview of immunological & virological factors driving the evolution & global spread of SARS-CoV-2 variants.

The SARS-CoV-2, a highly infectious positive strand RNA virus first identified in December 2019, has produced multiple genetic variants that have rapidly and sequentially spread worldwide during the coronavirus disease 2019 (COVID-19) pandemic. Genetic changes in SARS-CoV-2 for greater infectivity, replication and transmission were selected during the early stages of the pandemic. More recently, after widespread infection and vaccination, SARS-CoV-2 variants that evade antigen-specific adaptive immunity, have begun to be selected. This article provides an overview of the molecular immunological and virological factors underlying the origin and global spread of important SARS-CoV-2 variant lineages.

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来源期刊

Indian Journal of Medical Research 医学-免疫学

CiteScore

5.80

自引率

2.40%

发文量

191

审稿时长

3-8 weeks

期刊介绍： The Indian Journal of Medical Research (IJMR) [ISSN 0971-5916] is one of the oldest medical Journals not only in India, but probably in Asia, as it started in the year 1913. The Journal was started as a quarterly (4 issues/year) in 1913 and made bimonthly (6 issues/year) in 1958. It became monthly (12 issues/year) in the year 1964.