图像引导下子宫颈癌高剂量率间质近距离放射治疗对盆腔淋巴结区域剂量的评估。

IF 1.1 4区 医学 Q4 ONCOLOGY
Journal of Contemporary Brachytherapy Pub Date : 2023-08-01 Epub Date: 2023-08-31 DOI:10.5114/jcb.2023.130992
Ajeet Kumar Gandhi, Madhup Rastogi, Vachaspati Kumar Mishra, Anoop Kumar Srivastava, Farhana Khatoon, Daya Nand Sharma
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引用次数: 0

摘要

目的:如果腔内近距离放射治疗(ICRT)不可行,则间质近距离放射疗法(ISBT)适用于完整性宫颈癌(IN-CC),也适用于拱顶癌(VA-C)。我们旨在评估ISBT治疗in-CC和VA-C的盆腔淋巴结区域的剂量。材料和方法:选择10名患者(6名in-CC,4名VA-C)进行剂量测定研究。IN-CC除了针头外还有一个中央串联。描绘了髂外(EI-N)、髂内(II-N)、闭孔(OB-N)和骶骨(SA-N)组的淋巴结。in-CC和VA-C中的靶分别给药10格雷(Gy)和8 Gy,每个×2级。评估100%、90%和50%体积(D100、D90、D50)和D2cc、D1cc、D0.1cc接受的剂量。使用Student t检验比较in-CC和VA-C中淋巴结组的剂量。结果:对于20个植入物,针头的中位数为18(范围16-20)。双侧OB-N、II-N、EI-N和SA-N联合组的平均D90和D2cc分别为规定剂量的33.62±3.46%和102.94±10.71%、6.98±0.65%和39.69±3.64%、5.1±0.51%和15.4±0.8%、7.76±0.95%和15.36±1.09%。与VA-C相比,中央串联(IN-CC)患者接受的髂外、髂内和骶骨组淋巴结剂量明显更高(p<0.001)。结论:在接受ISBT治疗的宫颈癌患者中,盆腔淋巴结组接受了显著剂量。与术后患者相比,使用中央串联的完整癌症患者对盆腔淋巴结的剂量贡献更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evaluation of doses to pelvic lymph node regions from image-guided high-dose-rate interstitial brachytherapy for carcinoma of the uterine cervix.

Evaluation of doses to pelvic lymph node regions from image-guided high-dose-rate interstitial brachytherapy for carcinoma of the uterine cervix.

Purpose: Interstitial brachytherapy (ISBT) is indicated for intact cervical carcinoma (IN-CC) if intracavitary brachytherapy (ICRT) is not feasible and also in vault carcinoma (VA-C). We aimed to evaluate the doses to pelvic lymph node regions in IN-CC and VA-C treated with ISBT.

Material and methods: Ten patients (6 IN-CC, 4 VA-C) were chosen for this dosimetric study. IN-CC had a central tandem in addition to the needles. External iliac (EI-N), internal iliac (II-N), obturator (OB-N) and sacral (SA-N) groups of lymph nodes were delineated. A dose of 10 grays (Gy) and 8 Gy each × 2 fractions was prescribed to the target in IN-CC and VA-C respectively. Doses received by 100%, 90% and 50% volume (D100, D90, D50) and D2cc, D1cc, D0.1cc were evaluated. Doses to lymph nodal groups in IN-CC vs. VA-C were compared using Student's t-test.

Results: For 20 implants, the median number of needles was 18 (range, 16-20). Mean D90 and D2cc of the combined bilateral OB-N, II-N, EI-N and SA-N groups were 33.62 ±3.46% and 102.94 ±10.71%, 6.98 ±0.65% and 39.69 ±3.64%, 5.1 ±0.51% and 15.4 ±0.8%, 7.76 ±0.95% and 15.36 ±1.09% of the prescribed doses respectively. Patients with a central tandem (IN-CC) received significantly higher doses to external, internal iliac and sacral group of lymph nodes (p < 0.001) as compared to VA-C.

Conclusions: In patients with cervical carcinoma treated with ISBT, pelvic lymph node groups received significant doses. The dose contribution to pelvic lymph nodes is higher in patients with intact cervical cancer where a central tandem is used as compared to post-operative patients.

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来源期刊
Journal of Contemporary Brachytherapy
Journal of Contemporary Brachytherapy ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
2.40
自引率
14.30%
发文量
54
审稿时长
16 weeks
期刊介绍: The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.
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