慢性应激对大鼠膀胱形态的影响以及舒适饮食作为改善剂的影响。

IF 2.6 4区 心理学 Q2 BEHAVIORAL SCIENCES
Roger G Marchon, Bianca M Gregório, Marco A Pereira-Sampaio, Waldemar S Costa, Francisco J Sampaio, Diogo B De Souza
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引用次数: 0

摘要

目的:探讨慢性应激对应激大鼠膀胱形态的影响以及食物偏好(标准或舒适食物)对膀胱的影响。方法:Wistar雄性大鼠32只(3 月龄)分为四组:对照组(C)、应激组(S)、对照组 + 舒适食品(C + CF),并应力 + 舒适食品 + CF)。C组和C组 + CF维持在正常条件下,而S组和S组 + 采用约束法对CF进行慢性应激。C组和S组接受标准大鼠饲料,而C组 + CF和S + CF接受了舒适食品(Froot Loops®)和标准食物。每天诱导应激刺激2 h超过8 周。8点之后 数周后,处死所有动物,取出膀胱进行组织形态计量学分析。结果:各组的体重相似。压力并没有促进食物摄入的差异,但接受舒适食物的动物比只接受标准食物的动物显示出更高的卡路里摄入(以kcal/Kg为单位)。C + CF和S + CF组更喜欢舒适食物而不是标准食物;这种偏好在S中更高 + CF比C + CF组。应激组平滑肌表面密度降低,结缔组织和弹性系统纤维含量增加。此外,慢性应激大鼠的上皮高度增加。弹性体系纤维的表面密度因食用舒适食品而降低。结论:慢性应激可引起膀胱壁和上皮细胞的形态学改变。这些改变可能与下尿路症状有关。此外,慢性压力导致更倾向于摄入舒适的食物,这并没有改善或加剧压力引起的膀胱改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of chronic stress on bladder morphology of rats and impact of comfort food diet as an ameliorating agent.

Objectives: To investigate the effects of chronic stress on bladder morphology and the impact of food preference (standard or comfort foods) on the bladder of stressed rats.

Methods: In total, 32 Wistar male rats (3 months old) were divided into four groups: control (C), stressed (S), control + comfort food (C + CF), and stressed + comfort food (S + CF). Groups C and C + CF were maintained under normal conditions, while groups S and S + CF were subjected to chronic stress by the restraint method. Groups C and S received standard rat chow, while groups C + CF and S + CF received comfort food (Froot Loops®) and standard chow. The stress stimuli were induced daily for 2 h over 8 weeks. After 8 weeks, all animals were killed, and the bladders were removed and used for histomorphometric analysis.

Results: Body mass was similar among the groups. Stress did not promote differences regarding food intake, but animals receiving comfort food showed higher calories intake (in kcal/Kg) than animals receiving only standard chow. The C + CF and S + CF groups preferred comfort food over the standard chow; this preference was higher in the S + CF than in the C + CF group. The surface density of smooth muscle was reduced in stressed animals, while connective tissue and elastic system fiber content were increased in stressed groups. Further, epithelial height was increased in rats submitted to chronic stress. The surface density of elastic system fibers was decreased by the consumption of comfort food.

Conclusions: Chronic stress induces morphological modifications on the bladder wall and epithelium. These modifications may be related to lower urinary tract symptoms. Additionally, chronic stress caused a higher preference for comfort food intake which did not ameliorate or aggravate the stress-induced bladder alterations.

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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
25
审稿时长
6-12 weeks
期刊介绍: The journal Stress aims to provide scientists involved in stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic/knockout animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, neuroimaging, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.
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