组蛋白乙酰化、BET蛋白和牙周炎症。

IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Molecular Oral Microbiology Pub Date : 2024-08-01 Epub Date: 2023-10-06 DOI:10.1111/omi.12438
Nicholas Clayton, David Pellei, Zhao Lin
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引用次数: 0

摘要

牙周炎是人类最常见的炎症性疾病之一。牙周炎的易感性在很大程度上取决于宿主的反应,炎症的严重程度可以预测疾病的进展。在微生物损伤后,宿主细胞的转录程序发生巨大变化,从而引发适当的反应(炎症)。成功的关键病原体已经发展出操纵宿主细胞中基因表达网络的特定机制,这并不奇怪。新出现的数据表明,表观遗传学调控在炎症中起着重要作用。组蛋白赖氨酸残基的乙酰化是染色质的主要表观遗传学修饰,与染色质的可及性和转录的激活高度相关。在包括牙周炎在内的炎症性疾病中观察到特定的组蛋白乙酰化模式。溴和末端外结构域(BET)蛋白识别乙酰化组蛋白,然后将转录因子和转录延伸复合物募集到染色质。BET蛋白在炎症性疾病中受到调节,阻断BET蛋白功能的小分子是治疗炎症性疾病的有前景的“表观药物”。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histone acetylation, BET proteins, and periodontal inflammation.

Periodontitis is one of the most common inflammatory diseases in humans. The susceptibility to periodontitis is largely determined by the host response, and the severity of inflammation predicts disease progression. Upon microbial insults, host cells undergo massive changes in their transcription program to trigger an appropriate response (inflammation). It is not surprising that successful keystone pathogens have developed specific mechanisms to manipulate the gene expression network in host cells. Emerging data has indicated that epigenetic regulation plays a significant role in inflammation. Acetylation of lysine residues on histones is a major epigenetic modification of chromatin, highly associated with the accessibility of chromatin and activation of transcription. Specific histone acetylation patterns are observed in inflammatory diseases including periodontitis. Bromo- and extraterminal domain (BET) proteins recognize acetylated histones and then recruit transcription factors and transcription elongation complexes to chromatin. BET proteins are regulated in inflammatory diseases and small molecules blocking the function of BET proteins are promising "epi-drugs" for treating inflammatory diseases.

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来源期刊
Molecular Oral Microbiology
Molecular Oral Microbiology DENTISTRY, ORAL SURGERY & MEDICINE-MICROBIOLOGY
CiteScore
6.50
自引率
5.40%
发文量
46
审稿时长
>12 weeks
期刊介绍: Molecular Oral Microbiology publishes high quality research papers and reviews on fundamental or applied molecular studies of microorganisms of the oral cavity and respiratory tract, host-microbe interactions, cellular microbiology, molecular ecology, and immunological studies of oral and respiratory tract infections. Papers describing work in virology, or in immunology unrelated to microbial colonization or infection, will not be acceptable. Studies of the prevalence of organisms or of antimicrobials agents also are not within the scope of the journal. The journal does not publish Short Communications or Letters to the Editor. Molecular Oral Microbiology is published bimonthly.
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