植物多糖抗癌活性研究进展。

Qiaoyan Liu, Bo Song, Sen Tong, Qiuqiong Yang, Huanhuan Zhao, Jia Guo, Xuexia Tian, Renjie Chang, Junzi Wu
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引用次数: 0

摘要

肿瘤是对人类健康的严重威胁,发病率和死亡率极高。然而,肿瘤治疗具有挑战性,抗肿瘤药物的开发一直是一个重要的研究热点。众所周知,植物多糖具有多种生物活性。它们具有许多药理学特性,如免疫调节、抗肿瘤、抗病毒、抗氧化、抗血栓和抗辐射作用、降低血压和血糖水平以及防止肝损伤。在这些作用中,植物多糖的抗肿瘤作用已被广泛研究。植物多糖通过抑制肿瘤细胞侵袭转移、诱导细胞凋亡、影响细胞周期、调节肿瘤微环境等途径抑制肿瘤增殖和生长。它们还具有安全、高效、低毒的特点,可以在一定程度上缓解手术、放疗、化疗等传统肿瘤治疗方法引起的不良反应。因此,本文系统总结了植物多糖的直接抗肿瘤作用、对肿瘤微环境的调节作用,以及以其他方式干预许多常见的高发肿瘤。它还为植物多糖在现代肿瘤药物治疗中的给药提供了数据支持,使肿瘤治疗的新靶点的识别和新药的开发成为可能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Progress on the Anticancer Activity of Plant Polysaccharides.

Tumor is a serious threat to human health, with extremely high morbidity and mortality rates. However, tumor treatment is challenging, and the development of antitumor drugs has always been a significant research focus. Plant polysaccharides are known to possess various biological activities. They have many pharmacological properties such as immunomodulation, antitumor, antiviral, antioxidative, antithrombotic, and antiradiation effects, reduction of blood pressure and blood sugar levels, and protection from liver injury. Among these effects, the antitumor effect of plant polysaccharides has been widely studied. Plant polysaccharides can inhibit tumor proliferation and growth by inhibiting tumor cell invasion and metastasis, inducing cell apoptosis, affecting the cell cycle, and regulating the tumor microenvironment. They also have the characteristics of safety, high efficiency, and low toxicity, which can alleviate, to a certain extent, the adverse reactions caused by traditional tumor treatment methods such as surgery, radiotherapy, and chemotherapy. Therefore, this paper systematically summarizes the direct antitumor effects of plant polysaccharides, their regulatory effects on the tumor microenvironment, and intervening many common high-incidence tumors in other ways. It also provides data support for the administration of plant polysaccharides in modern tumor drug therapy, enabling the identification of new targets and development of new drugs for tumor therapy.

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