探讨血浆脂联素、瘦素和COMT基因型对绝经后妇女血压的影响。

IF 2.4 Q3 NUTRITION & DIETETICS
Journal of Nutritional Science Pub Date : 2023-09-19 eCollection Date: 2023-01-01 DOI:10.1017/jns.2023.75
Lauren Green, Laura Byham-Gray, Mindy Kurzer, Hamed Samavat
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引用次数: 0

摘要

研究表明,脂联素、瘦素和儿茶酚-O-甲基转移酶(COMT)基因型等遗传多态性可能在血压状况和心血管健康中发挥着不可或缺的作用。这对绝经后的妇女来说是一个特别重要的领域;然而,目前研究这些关联的文献是有限的。本研究是对明尼苏达绿茶试验(MGTT)的基线数据(N237)进行的横断面二次分析。本研究探讨了血浆脂联素、瘦素和COMT基因型在血压测量中的关系。在禁食至少10小时过夜后获得血浆脂联素和瘦素,并通过放射免疫分析法测量。在校正了潜在的混杂因素后,使用多元线性回归分析了这些关系。还研究了年龄、体重指数(BMI)类别、血压类别、抗高血压药物使用和COMT基因型对疗效的影响。大多数参与者是非西班牙裔(97·9%)和高加索人(94·9%)。平均(sd)年龄和BMI分别为60·7(5·0)岁和28·2(2·9)kg/m2。校正混杂变量后,血浆脂联素、血浆瘦素和COMT基因型均与收缩压或舒张压测量值无关。分层分析的结果也没有发现任何显著的相互作用或关联。根据这项研究的结果,脂联素、瘦素和COMT基因型都没有在绝经后女性的血压测量中发挥作用。这项研究使用了比以前更严格的统计方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploration of plasma adiponectin, leptin, and <i>COMT</i> genotype on blood pressure among women who are post-menopause.

Exploration of plasma adiponectin, leptin, and <i>COMT</i> genotype on blood pressure among women who are post-menopause.

Exploration of plasma adiponectin, leptin, and <i>COMT</i> genotype on blood pressure among women who are post-menopause.

Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause.

Research suggests that adiponectin, leptin, and genetic polymorphisms such as catechol-O-methyltransferase (COMT) genotype may play an integral role in blood pressure status and thereby cardiovascular health. This is an area especially important for women who are post-menopause; however, the current literature investigating these associations is limited. This study was a cross-sectional secondary analysis of baseline data (N 237) from the Minnesota Green Tea Trial (MGTT). The current study explored the relationships between plasma adiponectin, leptin, and COMT genotype on blood pressure measures. Plasma adiponectin and leptin were obtained after an overnight fast of at least 10 h and were measured by the radioimmunoassay method. The relationships were analysed using multiple linear regression after adjusting for potential confounders. Effect modifications by age, body mass index (BMI) category, blood pressure category, antihypertensive medication use, and COMT genotype were also investigated. The majority of participants were non-Hispanic (97⋅9 %) and Caucasian (94⋅9 %). Mean (sd) age and BMI were 60⋅7 (5⋅0) years and 28⋅2 (2⋅9) kg/m2, respectively. After adjustment for confounding variables, neither plasma adiponectin, plasma leptin nor COMT genotype was associated with systolic or diastolic blood pressure measures. The results of stratified analyses also did not reveal any significant interactions or associations. Based on the findings of this study, which utilised more rigorous statistical methods than previous research, neither adiponectin, leptin nor COMT genotype play a role in blood pressure measures in women who are post-menopause.

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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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