2型糖尿病患者无论肾小球滤过率降低,贫血合并蛋白尿都会增加心血管和肾脏事件的风险:一项前瞻性观察性研究。

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM
Diabetology International Pub Date : 2023-05-30 eCollection Date: 2023-10-01 DOI:10.1007/s13340-023-00637-x
Hiroyuki Ito, Suzuko Matsumoto, Hideyuki Inoue, Takuma Izutsu, Eiji Kusano, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane
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引用次数: 0

摘要

目的:在一项前瞻性观察性研究中,对2型糖尿病患者的心血管和肾脏事件的发生率进行调查,这些患者根据贫血和透析非依赖性慢性肾脏疾病(CKD)的组成进行分类。方法:对778名日本2型糖尿病患者进行为期4年的前瞻性分析。结果是心血管事件和肾脏事件的发生率。结果:在所有受试者中,心血管和肾脏事件的发生率分别为5%和11%。即使在调整了估计肾小球滤过率(eGFR2)的降低后,贫血和蛋白尿患者的心血管事件发生率也显著高于无贫血和白蛋白尿患者(危险比[HR]:5.73)。即使在调整了eGFR降低后,没有贫血和蛋白尿的患者的肾事件发生率(HR:2.93)显著高于没有贫血和白蛋白尿的患者(HR:7.56)。结论:贫血合并蛋白尿是2型糖尿病患者血管事件的危险因素,无论eGFR如何。补充信息:在线版本包含可在10.1007/s13340-023-00637-x上获得的补充材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anemia combined with albuminuria increases the risk of cardiovascular and renal events, regardless of a reduced glomerular filtration rate, in patients with type 2 diabetes: a prospective observational study.

Aim: The incidence of cardiovascular and renal events was investigated in patients with type 2 diabetes who were classified according to anemia and the components of dialysis-independent chronic kidney disease (CKD) in a prospective observational study.

Methods: A population of 778 Japanese patients with type 2 diabetes was prospectively analyzed for 4 years. The outcomes were the incidence of cardiovascular events and renal events.

Results: In all subjects, the incidence of cardiovascular and renal events was found to be 5% and 11%, respectively. Even after adjusting for a reduced estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2), the incidence of cardiovascular events was significantly higher (hazard ratio [HR]: 5.73) in patients with anemia and albuminuria than in those without anemia and albuminuria. The incidence of renal events was significantly higher in patients with no anemia and albuminuria (HR: 2.93) and further in those with anemia and albuminuria (HR: 7.56) than in those without anemia and albuminuria even after adjusting for a reduced eGFR.

Conclusion: Anemia combined with albuminuria is a risk factor for vascular events in patients with type 2 diabetes, regardless of the eGFR.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-023-00637-x.

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来源期刊
Diabetology International
Diabetology International ENDOCRINOLOGY & METABOLISM-
CiteScore
3.90
自引率
4.50%
发文量
42
期刊介绍: Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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