使用冠醚衍生柱进行分析和制备手性超临界流体色谱分离。

IF 2.8 4区 化学 Q2 CHEMISTRY, ANALYTICAL
Chirality Pub Date : 2023-09-22 DOI:10.1002/chir.23621
Lei Yue, Larry Miller, John Reilly
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引用次数: 0

摘要

在本研究中,使用12种伯胺在SFC条件下评估了冠醚衍生柱Crownpak®CR-I(+),并将色谱结果与8种固定化多糖基柱进行了比较。Crownpak®CR-I(+)的成功率明显更高。研究发现,向改性剂中添加5%的水显著改善了Crownpak®CR-I(+)上伯胺手性分离的峰形状。显示了首次报道的在Crownpak®CR-I(+)上的制备性SFC分离,为伯胺的制备分离提供了一种新的方法。案例研究表明,Crownpak®CR-I(+)是一种非常有用的柱,可用于制药行业中含有伯胺基团的具有挑战性的化合物的手性分离。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Analytical and preparative chiral supercritical fluid chromatography resolutions using crown ether-derived column

Analytical and preparative chiral supercritical fluid chromatography resolutions using crown ether-derived column

In this study, crown ether-derived column Crownpak® CR-I (+) was evaluated under SFC conditions using 12 primary amines, and the chromatographic results were compared against eight immobilized polysaccharide-based columns. Crownpak® CR-I (+) achieved a significantly higher success rate. It was found that the addition of 5% water to the modifier dramatically improved the peak shape for chiral separation of primary amines on Crownpak® CR-I (+). The first reported preparative SFC separations on Crownpak® CR-I (+) are shown, offering a new approach for the preparative resolution of primary amines. The case studies demonstrate that Crownpak® CR-I (+) is a very useful column in the chiral separation of challenging compounds that contain a primary amine group in the pharmaceutical industry.

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来源期刊
Chirality
Chirality 医学-分析化学
CiteScore
4.40
自引率
5.00%
发文量
124
审稿时长
1 months
期刊介绍: The main aim of the journal is to publish original contributions of scientific work on the role of chirality in chemistry and biochemistry in respect to biological, chemical, materials, pharmacological, spectroscopic and physical properties. Papers on the chemistry (physiochemical, preparative synthetic, and analytical), physics, pharmacology, clinical pharmacology, toxicology, and other biological aspects of chiral molecules will be published.
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