根据糖化血红蛋白水平分层的糖尿病前期患者对2019年住院期间冠状病毒疾病严重程度的影响。

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM
Diabetology International Pub Date : 2023-07-01 eCollection Date: 2023-10-01 DOI:10.1007/s13340-023-00643-z
Seizaburo Masuda, Tetsuya Yamada, Nozomi Hanzawa
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引用次数: 0

摘要

目的:糖化血红蛋白(HbA1c)水平为5.7的糖尿病前期患者 - 6.4%与2019冠状病毒病(新冠肺炎)的不良预后相关,但血糖控制程度是否与新冠肺炎严重程度相关尚不清楚。本研究的目的是评估糖尿病前期患者血糖控制程度与新冠肺炎严重程度之间的关系。材料和方法:我们回顾了2020年4月至2021年9月期间我院收治的254名新冠肺炎患者。根据患者的HbA1c水平,将其分为低(HbA1c 结果:71例和88例患者分别有中度和高度糖尿病风险。六十三名和七名患者出现严重(需要无创氧气治疗)或危重(重症监护室入院或人工呼吸管理)新冠肺炎。多元逻辑回归分析显示,糖尿病的高风险与严重的新冠肺炎相关(P = 0.01),而糖尿病的中度风险没有(P = 0.17)。结论:糖尿病高危的糖尿病前期患者与入院期间最严重的新冠肺炎症状有关。我们的发现可能有助于更有效地将医疗资源分配给糖尿病前期患者的范围更窄的人群。补充信息:在线版本包含补充材料,网址为10.1007/s13340-023-00643-z。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of prediabetes with a high risk of diabetes stratified by glycated hemoglobin level on the severity of coronavirus disease 2019 during admission.

Objective: Prediabetes with a glycated hemoglobin (HbA1c) level of 5.7 - 6.4% is associated with a poor prognosis of coronavirus disease 2019 (COVID-19), but whether the degree of glycemic control is associated with COVID-19 severity is unknown. The aim of this study was to evaluate the association between the degree of glycemic control and COVID-19 severity in patients with prediabetes.

Materials and methods: We reviewed 254 patients with COVID-19 admitted to our hospital between April 2020 and September 2021. Based on their HbA1c level, patients were classified into low (HbA1c level < 5.7%), moderate (HbA1c level, 5.7 - 5.9%), and high risk of diabetes (HbA1c level, 6.0 - 6.4%). The association between risk of diabetes and the worst COVID-19 symptom in terms of severity during admission was evaluated using binary logistic regression analysis.

Results: Seventy-one and 88 patients had moderate and high risks of diabetes, respectively. Sixty-three and seven patients presented severe (requiring non-invasive oxygen therapy) or critical (intensive care unit admission or artificial respiratory management) COVID-19. The multivariate logistic regression analysis showed that a high risk of diabetes was correlated with severe COVID-19 (P = 0.01) after adjusting for baseline characteristics, whereas a moderate risk of diabetes was not (P = 0.17).

Conclusion: Prediabetes with a high risk of diabetes is associated with the worst COVID-19 symptom in terms of severity during admission. Our findings could aid in more efficient allocation of healthcare resources to a narrower population of prediabetic patients.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-023-00643-z.

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来源期刊
Diabetology International
Diabetology International ENDOCRINOLOGY & METABOLISM-
CiteScore
3.90
自引率
4.50%
发文量
42
期刊介绍: Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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