妊娠期糖尿病患者可在妊娠早期和晚期接受治疗,尤其是妊娠前超重患者:日本的一项横断面研究。

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM
Diabetology International Pub Date : 2023-07-16 eCollection Date: 2023-10-01 DOI:10.1007/s13340-023-00646-w
Ayaka Takemoto, Yoshio Nagai, Shin Kawanabe, Tomoko Nakagawa, Kaho Matsumoto, Jyunichi Hasegawa, Nao Suzuki, Yasushi Tanaka, Masakatsu Sone
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引用次数: 0

摘要

妊娠早期诊断妊娠期糖尿病(GDM)的意义一直存在争议。我们使用国际糖尿病与妊娠研究小组协会(IADPSG)的标准来调查临床背景和新生儿结局是否因妊娠早期或晚期诊断为GDM而不同。这是一项单中心观察性研究,于2012年11月至2020年3月在圣玛利亚那大学医院(日本川崎)进行。我们根据诊断时间比较了GDM患者的背景和围产期结果( 2;p = 0.001)。两组之间的围产期结果没有差异。然而,在早期GDM患者的亚组分析中,超重组中妊娠期大婴儿的患病率显著较高(分别为15.4%和2.1%;p = 0.008)。总之,在妊娠早期使用IADPSG标准的GDM患者可以得到治疗,尤其是在妊娠前超重的患者中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Patients with gestational diabetes mellitus may be treated in both early and late pregnancy, especially in patients with pre-pregnancy overweight: A cross-sectional study in Japan.

The significance of diagnosing gestational diabetes mellitus (GDM) in early pregnancy is controversial. We used the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria to investigate whether clinical background and neonatal outcomes differ depending on when GDM is diagnosed in early or late pregnancy. This was a single-center, observational study conducted between November 2012 and March 2020 at St. Marianna University Hospital (Kawasaki, Japan). We compared the background and perinatal outcomes of patients with GDM depending on the time of diagnosis (at < 24 gestational weeks or ≥ 24 weeks). Insulin sensitivity index, homeostasis model assessment of insulin resistance, and β-cell function were calculated from a 75-g oral glucose tolerance test. Stratified analysis was performed by pre-pregnancy BMI in patients with early GDM. As a result, in the 507 patients, 89.9% gave birth at our hospital. The pre-pregnancy BMI was significantly higher in patients with early GDM than in those with late GDM (the median [interquartile range], 22.7 [20.3, 26.3] and 21.5 [19.3, 23.8] kg/m2, respectively; p = 0.001). Perinatal outcomes were not different between the two groups. However, in the subgroup analysis of patients with early GDM, the prevalence of large-for-gestational-age infants was significantly higher in the group with overweight (15.4% vs 2.1%, respectively; p = 0.008). In conclusion, patients with GDM using the IADPSG criteria in early pregnancy may be treated, especially in patients with pre-pregnancy overweight.

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来源期刊
Diabetology International
Diabetology International ENDOCRINOLOGY & METABOLISM-
CiteScore
3.90
自引率
4.50%
发文量
42
期刊介绍: Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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