水肿和淋巴清除:分子机制和持续的挑战。

IF 6.7 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Jerome W Breslin
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引用次数: 0

摘要

水肿的解决仍然是一个重大的临床挑战。创伤休克、败血症或糖尿病等疾病通常涉及微血管通透性过高,从而导致组织和器官功能障碍。由于遗传原因、手术切除淋巴结或感染导致的淋巴功能不全会导致不同程度的组织肿胀,损害活动能力和免疫防御。治疗选择仅限于水肿的治疗,因为没有具体的治疗方法能够显著成功地改善微血管渗漏或淋巴功能受损。这篇综述考察了控制微血管通透性和淋巴清除的生理、细胞和分子机制,以及间质液形成和清除的各个过程的最新知识。讨论了以水肿为特征的临床条件以及潜在的未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Edema and lymphatic clearance: molecular mechanisms and ongoing challenges.

Resolution of edema remains a significant clinical challenge. Conditions such as traumatic shock, sepsis, or diabetes often involve microvascular hyperpermeability, which leads to tissue and organ dysfunction. Lymphatic insufficiency due to genetic causes, surgical removal of lymph nodes, or infections, leads to varying degrees of tissue swelling that impair mobility and immune defenses. Treatment options are limited to management of edema as there are no specific therapeutics that have demonstrated significant success for ameliorating microvascular leakage or impaired lymphatic function. This review examines current knowledge about the physiological, cellular, and molecular mechanisms that control microvascular permeability and lymphatic clearance, the respective processes for interstitial fluid formation and removal. Clinical conditions featuring edema, along with potential future directions are discussed.

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来源期刊
Clinical science
Clinical science 医学-医学:研究与实验
CiteScore
11.40
自引率
0.00%
发文量
189
审稿时长
4-8 weeks
期刊介绍: Translating molecular bioscience and experimental research into medical insights, Clinical Science offers multi-disciplinary coverage and clinical perspectives to advance human health. Its international Editorial Board is charged with selecting peer-reviewed original papers of the highest scientific merit covering the broad spectrum of biomedical specialities including, although not exclusively: Cardiovascular system Cerebrovascular system Gastrointestinal tract and liver Genomic medicine Infection and immunity Inflammation Oncology Metabolism Endocrinology and nutrition Nephrology Circulation Respiratory system Vascular biology Molecular pathology.
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