氮曲仑在AZACTAM中的稳定性

Farmaco (Societa chimica italiana : 1989) Pub Date : 2005-06-01 DOI:10.1016/j.farmac.2005.04.009

Marianna Zając , Anna Jelińska , Judyta Cielecka-Piontek , Irena Oszczapowicz

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引用次数: 5

摘要

研究了温度和相对湿度对AZACTAM中氨曲仑稳定性的影响。采用紫外检测的高效液相色谱法对氮曲南的浓度变化进行了跟踪。测定了在RH = 76.4%， T = 313、323、333、343、353 K和T = 343 K, RH = 50.9%、60.5%、66.5%、76.4%时，可逆反应z -氮曲南+ e -氮曲南和平行反应z -氮曲南→产物的一级速率常数。计算了这些反应的热力学参数——能量、焓和熵。

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Stability of aztreonam in AZACTAM

The influence of temperature and relative humidity on the stability of aztreonam in AZACTAM was investigated. Changes of the concentration of aztreonam were followed using the HPLC method with UV detection. The first-order rate constants of the reversible reaction of isomerization Z-aztreonam $\overset{}{⇌}$ E-aztreonam and the parallel reaction Z-aztreonam → products were determined at RH = 76.4% and T = 313, 323, 333, 343 and 353 K, and at T = 343 K and RH = 50.9%, 60.5%, 66.5% and 76.4%. The thermodynamic parameters—energy, enthalpy and entropy of these reactions were calculated.

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Farmaco (Societa chimica italiana : 1989)

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