长期暴露于MPTP的猴子嗅球中多巴胺能细胞的数量增加。

Synapse (New York, N.y.) Pub Date : 2007-12-01 DOI:10.1002/syn.20451

Silvia Belzunegui, Waldy San Sebastián, Pablo Garrido-Gil, Amaya Izal-Azcárate, Marianne Vázquez-Claverie, Berta López, Irene Marcilla, José Luis Lanciego, Maria Rosario Luquin

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引用次数: 32

摘要

我们研究了黑质纹状体损伤对猴子嗅觉酪氨酸羟化酶免疫反应(TH-ir)细胞的影响。这些TH-ir细胞大部分出现在嗅球的肾小球层，其中许多是未成熟但具有功能的多巴胺能神经元。在帕金森猴中，嗅觉多巴胺能神经元的数量比对照组增加了100%，但它们的表型没有改变。这种增加的TH-ir细胞群可能是神经细胞损失的直接后果，并有助于帕金森病患者报告的低氧。

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The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP.

We investigated the impact of the nigrostriatal lesion on the olfactory tyrosine hydroxylase-immunoreactive (TH-ir) cells in monkeys. The majority of these TH-ir cells appeared in the glomerular layer of the olfactory bulb and many were immature but functional dopaminergic neurons. In parkinsonian monkeys the number of olfactory dopaminergic neurons increased up to 100% as compared to controls, but their phenotype did not change. This increased TH-ir cell population might be a direct consequence of the nigral cell loss and contribute to the hyposmia reported by Parkinson's disease patients.

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Synapse (New York, N.y.)

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