Hirokazu Takahashi , Masayuki Iigo , Kôichi Ando , Tetsuya Tachibana , D. Michael Denbow , Mitsuhiro Furuse
{"title":"促甲状腺素释放激素对雏鸡体温的调节作用","authors":"Hirokazu Takahashi , Masayuki Iigo , Kôichi Ando , Tetsuya Tachibana , D. Michael Denbow , Mitsuhiro Furuse","doi":"10.1016/j.devbrainres.2005.03.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>To understand thermal regulation of neonatal chicks, the contribution of thyrotropin-releasing hormone (TRH), a key regulator of the hypothalamus–pituitary–thyroid axis, was investigated. Intracerebroventricular (i.c.v.) injection of TRH (5 and 20 μg) increased body temperature, but did not change plasma T</span><sub>3</sub> and T<sub>4</sub><span> concentrations. Intraperitoneal (i.p.) injection of triiodothyronine (T</span><sub>3</sub><span>) and thyroxine (T</span><sub>4</sub>) did not influence body temperature.</p><p><span><span>Thereafter, the relationships between TRH and the hypothalamus–pituitary–adrenal axis and sympathetic nervous system were further investigated. Central TRH stimulated both corticosterone and epinephrine release. The i.c.v. injection of a corticotropin-releasing factor </span>receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T</span><sub>3</sub> and T<sub>4</sub> concentrations. The i.p. injection of epinephrine did not induce hyperthermia. Therefore, the thermoregulatory response to TRH may differ in neonatal stages being dependent upon the stimulation of the hypothalamus–pituitary–adrenal axis rather than the hypothalamus–pituitary–thyroid axis.</p></div>","PeriodicalId":100369,"journal":{"name":"Developmental Brain Research","volume":"157 1","pages":"Pages 58-64"},"PeriodicalIF":0.0000,"publicationDate":"2005-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.devbrainres.2005.03.004","citationCount":"29","resultStr":"{\"title\":\"Regulation of body temperature by thyrotropin-releasing hormone in neonatal chicks\",\"authors\":\"Hirokazu Takahashi , Masayuki Iigo , Kôichi Ando , Tetsuya Tachibana , D. Michael Denbow , Mitsuhiro Furuse\",\"doi\":\"10.1016/j.devbrainres.2005.03.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>To understand thermal regulation of neonatal chicks, the contribution of thyrotropin-releasing hormone (TRH), a key regulator of the hypothalamus–pituitary–thyroid axis, was investigated. Intracerebroventricular (i.c.v.) injection of TRH (5 and 20 μg) increased body temperature, but did not change plasma T</span><sub>3</sub> and T<sub>4</sub><span> concentrations. Intraperitoneal (i.p.) injection of triiodothyronine (T</span><sub>3</sub><span>) and thyroxine (T</span><sub>4</sub>) did not influence body temperature.</p><p><span><span>Thereafter, the relationships between TRH and the hypothalamus–pituitary–adrenal axis and sympathetic nervous system were further investigated. Central TRH stimulated both corticosterone and epinephrine release. The i.c.v. injection of a corticotropin-releasing factor </span>receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T</span><sub>3</sub> and T<sub>4</sub> concentrations. The i.p. injection of epinephrine did not induce hyperthermia. Therefore, the thermoregulatory response to TRH may differ in neonatal stages being dependent upon the stimulation of the hypothalamus–pituitary–adrenal axis rather than the hypothalamus–pituitary–thyroid axis.</p></div>\",\"PeriodicalId\":100369,\"journal\":{\"name\":\"Developmental Brain Research\",\"volume\":\"157 1\",\"pages\":\"Pages 58-64\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.devbrainres.2005.03.004\",\"citationCount\":\"29\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental Brain Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165380605000866\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Brain Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165380605000866","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Regulation of body temperature by thyrotropin-releasing hormone in neonatal chicks
To understand thermal regulation of neonatal chicks, the contribution of thyrotropin-releasing hormone (TRH), a key regulator of the hypothalamus–pituitary–thyroid axis, was investigated. Intracerebroventricular (i.c.v.) injection of TRH (5 and 20 μg) increased body temperature, but did not change plasma T3 and T4 concentrations. Intraperitoneal (i.p.) injection of triiodothyronine (T3) and thyroxine (T4) did not influence body temperature.
Thereafter, the relationships between TRH and the hypothalamus–pituitary–adrenal axis and sympathetic nervous system were further investigated. Central TRH stimulated both corticosterone and epinephrine release. The i.c.v. injection of a corticotropin-releasing factor receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T3 and T4 concentrations. The i.p. injection of epinephrine did not induce hyperthermia. Therefore, the thermoregulatory response to TRH may differ in neonatal stages being dependent upon the stimulation of the hypothalamus–pituitary–adrenal axis rather than the hypothalamus–pituitary–thyroid axis.