促甲状腺素释放激素对雏鸡体温的调节作用

Hirokazu Takahashi , Masayuki Iigo , Kôichi Ando , Tetsuya Tachibana , D. Michael Denbow , Mitsuhiro Furuse
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引用次数: 29

摘要

为了了解新生雏鸡的热调节,研究了促甲状腺素释放激素(TRH)的作用,TRH是下丘脑-垂体-甲状腺轴的关键调节因子。脑室注射TRH(5和20 μg)可使体温升高,但对血浆T3和T4浓度无影响。腹腔注射三碘甲状腺原氨酸(T3)和甲状腺素(T4)对体温无影响。随后进一步研究TRH与下丘脑-垂体-肾上腺轴和交感神经系统的关系。中枢TRH刺激皮质酮和肾上腺素的释放。静脉注射促肾上腺皮质激素释放因子受体拮抗剂可减弱TRH引起的体温和皮质酮浓度变化,但不影响血浆T3和T4浓度。静脉注射肾上腺素未引起热疗。因此,新生儿阶段对TRH的体温调节反应可能不同,这取决于对下丘脑-垂体-肾上腺轴的刺激,而不是对下丘脑-垂体-甲状腺轴的刺激。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulation of body temperature by thyrotropin-releasing hormone in neonatal chicks

To understand thermal regulation of neonatal chicks, the contribution of thyrotropin-releasing hormone (TRH), a key regulator of the hypothalamus–pituitary–thyroid axis, was investigated. Intracerebroventricular (i.c.v.) injection of TRH (5 and 20 μg) increased body temperature, but did not change plasma T3 and T4 concentrations. Intraperitoneal (i.p.) injection of triiodothyronine (T3) and thyroxine (T4) did not influence body temperature.

Thereafter, the relationships between TRH and the hypothalamus–pituitary–adrenal axis and sympathetic nervous system were further investigated. Central TRH stimulated both corticosterone and epinephrine release. The i.c.v. injection of a corticotropin-releasing factor receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T3 and T4 concentrations. The i.p. injection of epinephrine did not induce hyperthermia. Therefore, the thermoregulatory response to TRH may differ in neonatal stages being dependent upon the stimulation of the hypothalamus–pituitary–adrenal axis rather than the hypothalamus–pituitary–thyroid axis.

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