Ariel Graff-Guerrero , Jorge González-Olvera , Ana Fresán , Diana Gómez-Martín , Juan Carlos Méndez-Núñez , Francisco Pellicer
{"title":"反复经颅磁刺激背外侧前额叶皮层增加对人类实验性疼痛的耐受性","authors":"Ariel Graff-Guerrero , Jorge González-Olvera , Ana Fresán , Diana Gómez-Martín , Juan Carlos Méndez-Núñez , Francisco Pellicer","doi":"10.1016/j.cogbrainres.2005.05.002","DOIUrl":null,"url":null,"abstract":"<div><p>Dorsolateral prefrontal cortex (DLPFCx) has been implicated in pain perception and in a pain modulation pathway. However, the precise participation of this region is not completely understood. The aim of this study was to evaluate whether 1 Hz rTMS of DLPFCx modifies threshold and tolerance in experimental pain.</p><p>The effect of 1 Hz rTMS during 15 min at 100% motor threshold was tested in one hundred and eighty right-handed healthy volunteers, using a parallel-group stimulation design. The stimulation sites were right or left DLPFCx, right or left motor cortex, vertex or sham. rTMS was applied in two experimental contexts: (1) To evaluate its transitory effect (interference or facilitation) during cold pressor threshold (CPTh) and tolerance (CPTt) and (2) to evaluate its long-term effect by stimulating before CPTh, CPTt, pain heat thermal threshold, pain pressure threshold and tolerance.</p><p>During rTMS of right DLPFCx, an increase in left hand CPTt (mean ± SD; 17.63 s ± 5.58 to 30.94 s ± 14.84, <em>P</em> < 0.001) and in right hand CPTt (18.65 s ± 6.47 to 26.74 s ± 11.85, <em>P</em> < 0.001) were shown. No other stimulation site modified any of the pain measures during or after rTMS.</p><p>These results show that 1 Hz rTMS of right DLPFCx has a selective effect by increasing pain tolerance and also sustains a right hemisphere preference in pain processing.</p></div>","PeriodicalId":100287,"journal":{"name":"Cognitive Brain Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cogbrainres.2005.05.002","citationCount":"135","resultStr":"{\"title\":\"Repetitive transcranial magnetic stimulation of dorsolateral prefrontal cortex increases tolerance to human experimental pain\",\"authors\":\"Ariel Graff-Guerrero , Jorge González-Olvera , Ana Fresán , Diana Gómez-Martín , Juan Carlos Méndez-Núñez , Francisco Pellicer\",\"doi\":\"10.1016/j.cogbrainres.2005.05.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Dorsolateral prefrontal cortex (DLPFCx) has been implicated in pain perception and in a pain modulation pathway. However, the precise participation of this region is not completely understood. The aim of this study was to evaluate whether 1 Hz rTMS of DLPFCx modifies threshold and tolerance in experimental pain.</p><p>The effect of 1 Hz rTMS during 15 min at 100% motor threshold was tested in one hundred and eighty right-handed healthy volunteers, using a parallel-group stimulation design. The stimulation sites were right or left DLPFCx, right or left motor cortex, vertex or sham. rTMS was applied in two experimental contexts: (1) To evaluate its transitory effect (interference or facilitation) during cold pressor threshold (CPTh) and tolerance (CPTt) and (2) to evaluate its long-term effect by stimulating before CPTh, CPTt, pain heat thermal threshold, pain pressure threshold and tolerance.</p><p>During rTMS of right DLPFCx, an increase in left hand CPTt (mean ± SD; 17.63 s ± 5.58 to 30.94 s ± 14.84, <em>P</em> < 0.001) and in right hand CPTt (18.65 s ± 6.47 to 26.74 s ± 11.85, <em>P</em> < 0.001) were shown. No other stimulation site modified any of the pain measures during or after rTMS.</p><p>These results show that 1 Hz rTMS of right DLPFCx has a selective effect by increasing pain tolerance and also sustains a right hemisphere preference in pain processing.</p></div>\",\"PeriodicalId\":100287,\"journal\":{\"name\":\"Cognitive Brain Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.cogbrainres.2005.05.002\",\"citationCount\":\"135\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cognitive Brain Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0926641005001242\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cognitive Brain Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0926641005001242","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Repetitive transcranial magnetic stimulation of dorsolateral prefrontal cortex increases tolerance to human experimental pain
Dorsolateral prefrontal cortex (DLPFCx) has been implicated in pain perception and in a pain modulation pathway. However, the precise participation of this region is not completely understood. The aim of this study was to evaluate whether 1 Hz rTMS of DLPFCx modifies threshold and tolerance in experimental pain.
The effect of 1 Hz rTMS during 15 min at 100% motor threshold was tested in one hundred and eighty right-handed healthy volunteers, using a parallel-group stimulation design. The stimulation sites were right or left DLPFCx, right or left motor cortex, vertex or sham. rTMS was applied in two experimental contexts: (1) To evaluate its transitory effect (interference or facilitation) during cold pressor threshold (CPTh) and tolerance (CPTt) and (2) to evaluate its long-term effect by stimulating before CPTh, CPTt, pain heat thermal threshold, pain pressure threshold and tolerance.
During rTMS of right DLPFCx, an increase in left hand CPTt (mean ± SD; 17.63 s ± 5.58 to 30.94 s ± 14.84, P < 0.001) and in right hand CPTt (18.65 s ± 6.47 to 26.74 s ± 11.85, P < 0.001) were shown. No other stimulation site modified any of the pain measures during or after rTMS.
These results show that 1 Hz rTMS of right DLPFCx has a selective effect by increasing pain tolerance and also sustains a right hemisphere preference in pain processing.
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