Stanley Juan C. Gutierrez , Fladmir de S. Claudino , Bagnólia A. Da Silva , Celso A. Câmara , Reinaldo N. de Almeida , Maria de Fátima V. de Souza , Marcelo S. Da Silva , Emídio V.L. Da-Cunha , José Maria Barbosa-Filho
{"title":"豚鼠回肠中具有松弛活性的nb -苯甲酰色胺衍生物","authors":"Stanley Juan C. Gutierrez , Fladmir de S. Claudino , Bagnólia A. Da Silva , Celso A. Câmara , Reinaldo N. de Almeida , Maria de Fátima V. de Souza , Marcelo S. Da Silva , Emídio V.L. Da-Cunha , José Maria Barbosa-Filho","doi":"10.1016/j.farmac.2005.04.001","DOIUrl":null,"url":null,"abstract":"<div><p>A series of derivatives analogous to <em>N<sup>b</sup></em>-benzoyltryptamine were synthesized by the Schotten–Bauman procedure. The products obtained were: <em>N<sup>b</sup></em>-4-methoxy-benzoyltryptamine, <em>N<sup>b</sup></em>-2,4-dimethoxy-benzoyltryptamine, <em>N<sup>b</sup></em>-3,4-dimethoxy-benzoyltryptamine, <em>N<sup>b</sup></em>-3,4-methylenedioxy-benzoyltryptamine and <em>N<sup>b</sup></em>-3,4,5-trimethoxy-benzoyltryptamine. They were characterized through the usual spectrometric methods (UV, IR, <sup>1</sup>H and <sup>13</sup><span>C NMR) and showed non-selective relaxant activity in guinea-pig ileum pre-contracted with acetylcholine, histamine and KCl.</span></p></div>","PeriodicalId":77128,"journal":{"name":"Farmaco (Societa chimica italiana : 1989)","volume":"60 6","pages":"Pages 475-477"},"PeriodicalIF":0.0000,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmac.2005.04.001","citationCount":"9","resultStr":"{\"title\":\"Nb-benzoyltryptamine derivatives with relaxant activity in guinea-pig ileum\",\"authors\":\"Stanley Juan C. Gutierrez , Fladmir de S. Claudino , Bagnólia A. Da Silva , Celso A. Câmara , Reinaldo N. de Almeida , Maria de Fátima V. de Souza , Marcelo S. Da Silva , Emídio V.L. Da-Cunha , José Maria Barbosa-Filho\",\"doi\":\"10.1016/j.farmac.2005.04.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A series of derivatives analogous to <em>N<sup>b</sup></em>-benzoyltryptamine were synthesized by the Schotten–Bauman procedure. The products obtained were: <em>N<sup>b</sup></em>-4-methoxy-benzoyltryptamine, <em>N<sup>b</sup></em>-2,4-dimethoxy-benzoyltryptamine, <em>N<sup>b</sup></em>-3,4-dimethoxy-benzoyltryptamine, <em>N<sup>b</sup></em>-3,4-methylenedioxy-benzoyltryptamine and <em>N<sup>b</sup></em>-3,4,5-trimethoxy-benzoyltryptamine. They were characterized through the usual spectrometric methods (UV, IR, <sup>1</sup>H and <sup>13</sup><span>C NMR) and showed non-selective relaxant activity in guinea-pig ileum pre-contracted with acetylcholine, histamine and KCl.</span></p></div>\",\"PeriodicalId\":77128,\"journal\":{\"name\":\"Farmaco (Societa chimica italiana : 1989)\",\"volume\":\"60 6\",\"pages\":\"Pages 475-477\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.farmac.2005.04.001\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Farmaco (Societa chimica italiana : 1989)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014827X05000819\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmaco (Societa chimica italiana : 1989)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014827X05000819","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Nb-benzoyltryptamine derivatives with relaxant activity in guinea-pig ileum
A series of derivatives analogous to Nb-benzoyltryptamine were synthesized by the Schotten–Bauman procedure. The products obtained were: Nb-4-methoxy-benzoyltryptamine, Nb-2,4-dimethoxy-benzoyltryptamine, Nb-3,4-dimethoxy-benzoyltryptamine, Nb-3,4-methylenedioxy-benzoyltryptamine and Nb-3,4,5-trimethoxy-benzoyltryptamine. They were characterized through the usual spectrometric methods (UV, IR, 1H and 13C NMR) and showed non-selective relaxant activity in guinea-pig ileum pre-contracted with acetylcholine, histamine and KCl.
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