-羟基丁酸:弥合临床分析差距。

Cynthia L Morris-Kukoski
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引用次数: 21

摘要

γ -羟基丁酸酯(GHB)的实验室检测早在20世纪60年代就已发表。然而,在20世纪90年代,GHB的大规模使用导致了目前的分析方法的发展,以测试GHB和相关化合物。GHB及相关化合物的检测在临床上可用于确认过量服用患者的昏迷原因,确定其在死后受害者中的潜在作用,以及评估其在药物性侵犯受害者中的应用。为了确定分析方法的有效性和临床应用,必须了解分析方法的灵敏度。大多数实验室的截止水平是基于仪器灵敏度,不能确定内源性和外源性GHB水平。对GHB水平的解释必须包括内源性GHB、GHB和相关化合物的代谢以及死后生成的知识基础。由于各种GHB方法存在潜在的分析局限性,因此,如果对GHB和相关GHB化合物也有疑问,则具体要求提供GHB和相关GHB化合物具有临床相关性。不同的储存条件(收集时间、容器类型、防腐剂的使用、储存温度)也会影响GHB和相关化合物的分析和解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gamma-hydroxybutyrate: bridging the clinical-analytical gap.

Laboratory detection of gamma-hydroxybutyrate (GHB) has been published as early as the 1960s. However, wide-scale use of GHB during the 1990s has led to the development of current analytic methods to test for GHB and related compounds. Detection of GHB and related compounds can be clinically useful in confirming the cause of coma in an overdose patient, determining its potential role in a postmortem victim, as well as evaluating its use in a drug-facilitated sexual assault victim. Analytical method sensitivity must be known in order to determine the usefulness and clinical application. Most laboratory cut-off levels are based on instrument sensitivity and will not establish endogenous versus exogenous GHB levels. Interpretation of GHB levels must include a knowledge base of endogenous GHB, metabolism of GHB and related compounds, as well as postmortem generation. Due to potential analytical limitations in various GHB methods, it is clinically relevant to specifically request for GHB as well as related GHB compounds if they are also in question. Various storage conditions (collection time, types of containers, use of preservatives, storage temperature) can also affect the analysis and interpretation of GHB and related compounds.

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