慢性丙型肝炎与库姆斯阳性溶血性贫血相关。

The hematology journal : the official journal of the European Haematology Association Pub Date : 2004-01-01 DOI:10.1038/sj.thj.6200400

Ihab I Elhajj, Ala' I Sharara, Ali T Taher

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引用次数: 15

摘要

丙型肝炎病毒(HCV)是公认的重要肝外疾病的病因。在HCV感染的干扰素(IFN)治疗期间或之后，已有诱导自身免疫性溶血性贫血(AIHA)的报道。我们在此报告一位56岁的HCV感染患者，在没有干扰素治疗的情况下发生了严重的coombs阳性AIHA。开始泼尼松治疗，但由于持续溶血，静脉注射免疫球蛋白。临床病程因病情迅速恶化和发展为克雅氏病而变得复杂。在排除了其他可能的AIHA病因后，我们认为AIHA与HCV感染之间可能存在关联。

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Chronic hepatitis C associated with Coombs-positive hemolytic anemia.

Hepatitis C virus (HCV) is a recognized cause of significant extrahepatic disease. Induction of autoimmune hemolytic anemia (AIHA) has been reported, either during or after interferon (IFN) treatment of HCV infection. We herein report a 56-year-old patient with HCV infection who developed severe Coombs-positive AIHA in the absence of treatment with IFN. Prednisone therapy was initiated, but intravenous immunoglobulins were added because of persistent hemolysis. Clinical course was complicated by rapid deterioration and the development of Creutzfeldt-Jakob disease. Having discarded other possible causes of AIHA, we suggest a possible association between AIHA and infection by HCV.

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The hematology journal : the official journal of the European Haematology Association

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