HDL和动脉粥样硬化中的炎症。

Lukas E Spieker, Frank Ruschitzka, Thomas F Lüscher, Georg Noll
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引用次数: 24

摘要

动脉粥样硬化性血管疾病是全世界最常见的死亡原因之一。目前的治疗策略主要集中在降低低密度脂蛋白(LDL)胆固醇,并显著降低了心血管发病率和死亡率的风险。炎症机制在血管疾病中发挥着重要作用,炎症标志物与急性和慢性冠状动脉疾病的预后相关。高密度脂蛋白胆固醇对脉管系统有抗炎作用。此外,HDL是一种抗氧化剂,抑制血栓形成,并具有促纤溶特性。最后但并非最不重要的是,高密度脂蛋白介导逆向胆固醇运输。这些多效性作用使HDL成为新的治疗策略的理想治疗靶点,专门针对HDL升高预防和治疗动脉粥样硬化性血管疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HDL and inflammation in atherosclerosis.

Atherosclerotic vascular disease is among the most frequent causes of death worldwide. Current therapeutic strategies concentrate mainly on lowering of low-density lipoprotein (LDL) cholesterol and an impressive reduction in the risk for cardiovascular morbidity and mortality has been achieved. Inflammatory mechanisms are more and more recognized to play an important role in vascular disease as inflammatory markers correlate with prognosis in acute and chronic coronary artery disease. HDL cholesterol exerts anti-inflammatory effects on the vasculature. Moreover, HDL is an antioxidant, inhibits thrombogenesis, and has pro-fibrinolytic properties. Last but not least, HDL mediates reverse cholesterol transport. These pleiotropic effects make HDL an ideal therapeutic target for novel therapeutic strategies specifically aiming at HDL elevation for the prevention and treatment of atherosclerotic vascular disease.

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