{"title":"l -丙氨酸对针刺分枝杆菌d -环丝氨酸逆转作用的拮抗作用。","authors":"J MORA, L F BOJALIL","doi":"10.3181/00379727-119-30096","DOIUrl":null,"url":null,"abstract":"Summary Growth of Mycobacterium acapulcensis is inhibited by D-cycloserine. This effect is completely reversed by equimolecular concentrations of D-alanine. L-alanine is totally inactive while DL-alanine is only effective at higher concentrations. L-alanine antagonized the protection afforded by D-alanine, a fact that cannot be explained by a simple competition between these diastereoisomers at the cell membrane level. In the presence of D-cycloserine a mucopeptide accumulates in the sensitive strain and also in the resistant mutant when allowed to grow at high antibiotic concentrations.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"49-52"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30096","citationCount":"8","resultStr":"{\"title\":\"ANTAGONISM OF THE D-ALANINE REVERSAL OF D-CYCLOSERINE ACTION BY L-ALANINE IN MYCOBACTERIUM ACAPULCENSIS.\",\"authors\":\"J MORA, L F BOJALIL\",\"doi\":\"10.3181/00379727-119-30096\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Summary Growth of Mycobacterium acapulcensis is inhibited by D-cycloserine. This effect is completely reversed by equimolecular concentrations of D-alanine. L-alanine is totally inactive while DL-alanine is only effective at higher concentrations. L-alanine antagonized the protection afforded by D-alanine, a fact that cannot be explained by a simple competition between these diastereoisomers at the cell membrane level. In the presence of D-cycloserine a mucopeptide accumulates in the sensitive strain and also in the resistant mutant when allowed to grow at high antibiotic concentrations.\",\"PeriodicalId\":20675,\"journal\":{\"name\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"49-52\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1965-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3181/00379727-119-30096\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3181/00379727-119-30096\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30096","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ANTAGONISM OF THE D-ALANINE REVERSAL OF D-CYCLOSERINE ACTION BY L-ALANINE IN MYCOBACTERIUM ACAPULCENSIS.
Summary Growth of Mycobacterium acapulcensis is inhibited by D-cycloserine. This effect is completely reversed by equimolecular concentrations of D-alanine. L-alanine is totally inactive while DL-alanine is only effective at higher concentrations. L-alanine antagonized the protection afforded by D-alanine, a fact that cannot be explained by a simple competition between these diastereoisomers at the cell membrane level. In the presence of D-cycloserine a mucopeptide accumulates in the sensitive strain and also in the resistant mutant when allowed to grow at high antibiotic concentrations.
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