{"title":"豚鼠结核病的预防和结核菌素反应的逆转。","authors":"E A BROSBE, P T SUGIHARA, J M ADAMS","doi":"10.3181/00379727-119-30095","DOIUrl":null,"url":null,"abstract":"Summary Reversal of the tuberculin reaction occurred in 70% of animals treated with INH following development of a positive test. One year of INH treatment failed to sterilize the tissues in 15% of the animals. Evidence is presented that INH completely protected guinea pigs from tuberculosis when treatment was initiated prior to inoculation of a minimal dose. All non-treated controls developed visceral tuberculosis.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"46-9"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30095","citationCount":"2","resultStr":"{\"title\":\"PREVENTION OF TUBERCULOSIS AND REVERSAL OF TUBERCULIN REACTION IN GUINEA PIGS.\",\"authors\":\"E A BROSBE, P T SUGIHARA, J M ADAMS\",\"doi\":\"10.3181/00379727-119-30095\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Summary Reversal of the tuberculin reaction occurred in 70% of animals treated with INH following development of a positive test. One year of INH treatment failed to sterilize the tissues in 15% of the animals. Evidence is presented that INH completely protected guinea pigs from tuberculosis when treatment was initiated prior to inoculation of a minimal dose. All non-treated controls developed visceral tuberculosis.\",\"PeriodicalId\":20675,\"journal\":{\"name\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"46-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1965-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3181/00379727-119-30095\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3181/00379727-119-30095\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30095","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
PREVENTION OF TUBERCULOSIS AND REVERSAL OF TUBERCULIN REACTION IN GUINEA PIGS.
Summary Reversal of the tuberculin reaction occurred in 70% of animals treated with INH following development of a positive test. One year of INH treatment failed to sterilize the tissues in 15% of the animals. Evidence is presented that INH completely protected guinea pigs from tuberculosis when treatment was initiated prior to inoculation of a minimal dose. All non-treated controls developed visceral tuberculosis.
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