{"title":"异山梨酯，一种新型口服渗透利尿剂。","authors":"J F TREON, L E GONGWER, W H RUEGGEBERG","doi":"10.3181/00379727-119-30092","DOIUrl":null,"url":null,"abstract":"Summary Isosorbide has been shown to be an effective diuretic when given orally to rats. The urinary output is related to dosage with an 8- or 9-fold increase for the period of 4 hours following a dose of 10 g/kg of body weight. Based on carbon-14 studies, more than 95% of the administered dose is readily excreted largely unchanged in the urine. Because of its effectiveness and very low order of acute and sub-acute toxicity, isosorbide is considered as an orally effective osmotic diuretic.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"39-42"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30092","citationCount":"10","resultStr":"{\"title\":\"ISOSORBIDE, A NEW ORAL OSMOTIC DIURETIC.\",\"authors\":\"J F TREON, L E GONGWER, W H RUEGGEBERG\",\"doi\":\"10.3181/00379727-119-30092\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Summary Isosorbide has been shown to be an effective diuretic when given orally to rats. The urinary output is related to dosage with an 8- or 9-fold increase for the period of 4 hours following a dose of 10 g/kg of body weight. Based on carbon-14 studies, more than 95% of the administered dose is readily excreted largely unchanged in the urine. Because of its effectiveness and very low order of acute and sub-acute toxicity, isosorbide is considered as an orally effective osmotic diuretic.\",\"PeriodicalId\":20675,\"journal\":{\"name\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"39-42\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1965-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3181/00379727-119-30092\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3181/00379727-119-30092\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30092","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Summary Isosorbide has been shown to be an effective diuretic when given orally to rats. The urinary output is related to dosage with an 8- or 9-fold increase for the period of 4 hours following a dose of 10 g/kg of body weight. Based on carbon-14 studies, more than 95% of the administered dose is readily excreted largely unchanged in the urine. Because of its effectiveness and very low order of acute and sub-acute toxicity, isosorbide is considered as an orally effective osmotic diuretic.
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