Yamini Krishnan, Gazel S, Aswin Joy, Sreedharan P S, Reshmi J S, Sandhya S
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引用次数: 0
摘要
易位t (12;17) (p13;q21)是一种罕见的细胞遗传学事件，最常见于b前急性淋巴细胞白血病和急性髓性白血病。我们发现了一名免疫表型为早期T细胞前体急性淋巴细胞白血病ETP- ALL的儿童(12;17)(p13;Q21)易位作为主要核型异常。t(12;17)的关联(p13;q21)与ETP-ALL的合并在以前的文献中没有描述。正在讨论它是一种新的遗传异常或新描述的ETP/髓系MPAL实体的一部分的可能性。这种异常的检测可以改变ETP-ALL的预后。关键词:ETP- all, t(12;17) (p13;q21)易位，ETP- MPAL。
Childhood Early T Cell Precursor Acute Lymphoblastic Leukaemia with t(12;17) (p13;q21) Translocation - A Rare Entity or Part of ETP/Myeloid Mixed Phenotype Acute Leukaemia.
The translocation t (12;17) (p13; q21) is a rare cytogenetic event most commonly described in pre-B- acute lymphoblastic leukaemia and acute myeloid leukaemia. We identified a child with an immunophenotype of Early T Cell Precursor Acute Lymphoblastic Leukaemia ETP- ALL having t (12;17) (p13; q21) translocation as the primary karyotypic anomaly. The association of t (12;17) (p13; q21) with ETP-ALL has not been described previously in literature. The possibility of it being a novel genetic abnormality or a part of the newly described entity of ETP/myeloid MPAL is being discussed. Detection of such abnormalities can alter the prognosis of ETP-ALL. Key words: ETP-ALL , t(12;17) (p13;q21) translocation, ETP- MPAL.
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