抗体对加速乙肝疫苗接种过程的反应。

P C S Lian, B Morrish
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引用次数: 0

摘要

背景:乙型肝炎疫苗接种有几个疗程和不同的剂量间隔。这项独立研究观察了三次加速疗程后的抗体反应。目的:本研究的主要目的是检查职业健康服务中心提供的一个或两个加速乙肝病程抗体应答(如果无应答)的数据。第二个目的是确定不同性别和年龄组的反应是否存在差异。方法:这是一项回顾性匿名和盲法研究,观察1032名卫生保健人员在6年多的时间里加速接种乙肝疫苗的抗体反应。接种疫苗4个月后出现>10 IU/ml的抗hbs应答,即为应答。结果:一个疗程后,93%的医护人员产生了被认为具有免疫力的抗体水平。经过两个疗程后,近99%的医护人员产生了足够的免疫反应。结论:加速疗程在4个月后提供高水平的免疫力,这支持了目前向英国医护人员提供加速剂量的做法,这些医护人员可能处于即时和较高的感染风险。虽然有些群体的反应较差,但所有群体的反应都很好,因此应鼓励所有有风险的人接种这种疫苗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibody response to an accelerated course of Hepatitis B vaccination.

Background: There are several courses with different dosing intervals for Hepatitis B vaccination. This independent study is looking at the antibody response after three doses of the accelerated course.

Aims: The primary aim of the study was to examine data available at an Occupational Health Service for the antibody response to one or if nonresponsive, two accelerated Hepatitis B courses. A secondary aim is to determine if there is a difference in response for different sex and age groups.

Methods: This is a retrospective anonymous and blinded study looking at the antibody response in 1032 healthcare personnel given the accelerated course of the Hepatitis B vaccine over a period of over 6 years. An anti-Hbs response 4 months after the start of the vaccination of >10 IU/ml was taken as indicative of a response.

Results: After one course, 93% of the healthcare personnel developed antibody levels thought to confer immunity. After two courses, nearly 99% of the healthcare personnel had developed an adequate immune response. The response was better in females and <40 years old, a difference that was statistically significant for those aged <40.

Conclusions: The accelerated course confers high levels of immunity after 4 months and this supports the current practice of offering the accelerated dose to UK healthcare personnel who can be at immediate and higher risk of infection. Though some groups are less responsive, all groups mount a good response so all those at risk should be encouraged to have this vaccination.

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