子宫内膜短暂性非典型淋巴浆细胞增生伴脓膜增生1例。

IF 1.1 Q4 ONCOLOGY
International journal of clinical and experimental pathology Pub Date : 2022-07-15 eCollection Date: 2022-01-01
Tomoyuki Otani, Kosuke Murakami, Masatomo Kimura, Mitsuru Matsuki, Takao Satou, Noriomi Matsumura, Akihiko Ito
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引用次数: 0

摘要

浆母细胞淋巴瘤是一种成熟的b细胞肿瘤,具有浆母细胞分化,通常与人类免疫缺陷病毒(HIV)感染和其他形式的免疫抑制有关。虽然它通常是一种侵袭性疾病,但在少数病例中也见过自发消退。子宫浆母细胞淋巴瘤是罕见的。我们报告一例非典型淋巴浆细胞增生,类似浆母细胞淋巴瘤合并脓膜肿大,随着脓膜肿大消退而完全消失。76岁女性hiv阴性,阴道异常出血。超声和MRI检查结果与脓膜炎的诊断一致。子宫内膜活检显示子宫内膜内有大量细胞质丰富、核仁明显的质母细胞样细胞增生。免疫组化显示大细胞CD138、CD79a和MUM1阳性,CD20、PAX5、CD3和CD5阴性。Ki67标记了至少80%的大细胞。在少量细胞中检测到eb病毒。组织学表现为淋巴瘤,尤其是浆母细胞淋巴瘤,尽管临床情况不寻常。随着子宫积脓的治疗和消退,宫内异常完全消失。16个月后,患者恢复良好,无复发迹象。这个病例强调了良性炎症和淋巴瘤之间有时模糊的区别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Transient atypical lymphoplasmacytic proliferation of the endometrium associated with pyometra: a case report.

Transient atypical lymphoplasmacytic proliferation of the endometrium associated with pyometra: a case report.

Plasmablastic lymphoma is a mature B-cell neoplasm with plasmablastic differentiation, often associated with human immunodeficiency virus (HIV) infection and other forms of immunosuppression. Although it is usually an aggressive disease, spontaneous regression has been seen in a few cases. Plasmablastic lymphoma of the uterus is rare. We report a case of atypical lymphoplasmacytic proliferation resembling plasmablastic lymphoma associated with pyometra that disappeared completely as the pyometra resolved. A 76-year-old HIV-negative woman presented with abnormal vaginal bleeding. Ultrasound and MRI findings were consistent with pyometra diagnosis. Endometrial biopsy revealed large plasmablastoid cells with abundant cytoplasm and prominent nucleoli proliferating in the endometrium. Immunohistochemistry showed that large cells stained positive for CD138, CD79a, and MUM1, and negative for CD20, PAX5, CD3, and CD5. Ki67 labelled at least 80% of the large cells. Epstein-Barr virus was detected in a small number of cells. The histologic picture was highly indicative of lymphoma, especially plasmablastic lymphoma, though the clinical context was unusual. As the pyometra was treated and resolved, the intrauterine abnormality disappeared completely. The patient has been well after 16 months with no sign of recurrent disease. This case underscores the sometimes blurry distinction between benign inflammation and lymphoma.

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来源期刊
自引率
0.00%
发文量
42
审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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