α -平滑肌肌动蛋白在牙源性囊肿和肿瘤中的表达。

Q3 Medicine
Malik Ajaz Ahmad, Anish Ashok Gupta, Shubhangi Ashok Mhaske, Swati Saawarn, Sahana Ashok, Dakshata Mandora, Megha Jain
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引用次数: 0

摘要

背景:牙源性囊肿和肿瘤在生物学行为上表现出不同程度的侵袭性。有证据表明,肌成纤维细胞(MFs)在侵袭前沿的存在促进了肿瘤的侵袭。我们的研究是基于MFs在牙源性囊肿和肿瘤的生物学行为中是重要的这一事实。目的:研究α-平滑肌肌动蛋白(α-SMA)在牙源性囊肿和肿瘤组织中的免疫组织化学表达及其与生物学行为的关系。材料和方法:收集了1.5年的档案组织,来自印度博帕尔人民牙科学院口腔病理与微生物学系。研究组共40例,其中牙源性角化囊肿、根状囊肿、牙源性囊肿、成釉细胞瘤各10例。免疫组织化学分析α-SMA的表达和定位。结果:平均MF数以牙源性角化囊肿最高,其次为成釉细胞瘤、整体囊肿和根状囊肿。50%的患者α- sma表达弱,22.5%的患者α- sma表达中度,10%的患者α- sma表达强烈。其中35例以纺锤形、焦状或网状排列;分别占27.5%和20%。结论:分析表明,MFs在分布和排列方式上具有明显的异质性。这提供了有说服力的证据,表明这些病变间质中含有α-SMA免疫阳性细胞所反映的MFs。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EXPRESSION OF ALPHA-SMOOTH MUSCLE ACTIN IN ODONTOGENIC CYSTS AND TUMORS.

Background: Odontogenic cysts and tumors exhibit different degrees of aggressiveness in their biological behavior. There has been evidence that the presence of myofibroblasts (MFs) at the invasion front promotes tumor invasion. Our study is based on the fact that MFs are important in the biological behavior of odontogenic cysts and tumors.

Aim: To assess immunohistochemically expression of alpha-smooth muscle actin (α-SMA) of MFs in odontogenic cysts and tumors and correlate this expression to their biological behavior.

Materials and methods: The archival tissues collected for 1.5 years were obtained from the Department of Oral Pathology & Microbiology, People's Dental Academy, Bhopal (India). A total of 40 cases consisting of 10 cases each of odontogenic keratocysts, radicular cysts, dentigerous cysts and ameloblastomas formed the study group. An immunohistochemical analysis of α-SMA expression and localization was carried out.

Results: Mean MF counts were the highest in odontogenic keratocysts which was followed by ameloblastomas, entigerous cysts and radicular cysts. Weak α-SMA-expression was found in 50% of cases, moderate in 22.5% of cases, and intense - in 10% cases. MFs were arranged in the spindle, focal, or network patterns in 35; 27.5 and 20% of cases, respectively.

Conclusion: The analysis revealed that the MFs were distinctly heterogeneous in distribution and pattern of arrangement. This provided persuasive evidence that stroma of these lesions harbor MFs as reflected by α-SMA immunopositive cells.

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来源期刊
Experimental oncology
Experimental oncology Medicine-Oncology
CiteScore
1.40
自引率
0.00%
发文量
49
期刊介绍: The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.
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