{"title":"平衡训练调节帕金森病患者的皮质抑制:一项随机对照试验","authors":"Hsin-Hsuan Liu, Ray-Yau Wang, Shih-Jung Cheng, Kwong-Kum Liao, Jun-Hong Zhou, Yea-Ru Yang","doi":"10.1177/15459683221119761","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Most individuals with Parkinson's disease (PD) develop balance dysfunction. Previous studies showed that individuals with PD have abnormal corticomotor changes related to severity of motor symptoms and disease progression. Cortical disinhibition was observed in PD and this alteration can be an early sign of PD. Balance training seems to be an effective intervention to improve balance in individuals with PD. However, it is not much known about the effect of balance training on cortical neuroplasticity in PD population.</p><p><strong>Objective: </strong>To investigate the effects of balance training on corticomotor excitability in individuals with PD.</p><p><strong>Methods: </strong>Twenty-eight PD participants were recruited and randomly assigned to either the balance training (BT) or the control (CON) group. Both groups underwent 16 training sessions over 8 weeks. Outcome measures for corticomotor inhibition included the cortical silent period (CSP) and short-interval intracortical inhibition (SICI) on transcranial magnetic stimulation. Balance performance was measured using the Mini-Balance Evaluation Systems Test (Mini-BEST) and the Timed Up and Go (TUG) test.</p><p><strong>Results: </strong>Participants in the BT group showed a significant increase in corticomotor inhibition (CSP: <i>P</i> = .028, SICI: <i>P</i> = .04) and a significant improvement in balance performance (Mini-BEST: <i>P</i> = .001, TUG: <i>P</i> = .04) after training. Compared to the CON group, the BT group showed a greater increase in corticomotor inhibition (CSP: <i>P</i> = .017, SICI: <i>P</i> = .046) and better improvement in balance (Mini-BEST: <i>P</i> = .046).</p><p><strong>Conclusion: </strong>Balance training could modulate corticomotor inhibition in the primary motor cortex and improve balance performance in individuals with PD.</p>","PeriodicalId":56104,"journal":{"name":"Neurorehabilitation and Neural Repair","volume":" ","pages":"613-620"},"PeriodicalIF":3.7000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Balance Training Modulates Cortical Inhibition in Individuals with Parkinson's Disease: A Randomized Controlled Trial.\",\"authors\":\"Hsin-Hsuan Liu, Ray-Yau Wang, Shih-Jung Cheng, Kwong-Kum Liao, Jun-Hong Zhou, Yea-Ru Yang\",\"doi\":\"10.1177/15459683221119761\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Most individuals with Parkinson's disease (PD) develop balance dysfunction. Previous studies showed that individuals with PD have abnormal corticomotor changes related to severity of motor symptoms and disease progression. Cortical disinhibition was observed in PD and this alteration can be an early sign of PD. Balance training seems to be an effective intervention to improve balance in individuals with PD. However, it is not much known about the effect of balance training on cortical neuroplasticity in PD population.</p><p><strong>Objective: </strong>To investigate the effects of balance training on corticomotor excitability in individuals with PD.</p><p><strong>Methods: </strong>Twenty-eight PD participants were recruited and randomly assigned to either the balance training (BT) or the control (CON) group. Both groups underwent 16 training sessions over 8 weeks. Outcome measures for corticomotor inhibition included the cortical silent period (CSP) and short-interval intracortical inhibition (SICI) on transcranial magnetic stimulation. Balance performance was measured using the Mini-Balance Evaluation Systems Test (Mini-BEST) and the Timed Up and Go (TUG) test.</p><p><strong>Results: </strong>Participants in the BT group showed a significant increase in corticomotor inhibition (CSP: <i>P</i> = .028, SICI: <i>P</i> = .04) and a significant improvement in balance performance (Mini-BEST: <i>P</i> = .001, TUG: <i>P</i> = .04) after training. Compared to the CON group, the BT group showed a greater increase in corticomotor inhibition (CSP: <i>P</i> = .017, SICI: <i>P</i> = .046) and better improvement in balance (Mini-BEST: <i>P</i> = .046).</p><p><strong>Conclusion: </strong>Balance training could modulate corticomotor inhibition in the primary motor cortex and improve balance performance in individuals with PD.</p>\",\"PeriodicalId\":56104,\"journal\":{\"name\":\"Neurorehabilitation and Neural Repair\",\"volume\":\" \",\"pages\":\"613-620\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurorehabilitation and Neural Repair\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15459683221119761\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/8/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurorehabilitation and Neural Repair","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15459683221119761","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/8/25 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 3
摘要
背景:大多数帕金森病患者会出现平衡功能障碍。先前的研究表明,PD患者存在与运动症状严重程度和疾病进展相关的异常皮质运动性改变。在PD中观察到皮层抑制解除,这种改变可能是PD的早期征兆。平衡训练似乎是一种有效的干预措施,以改善平衡个体PD。然而,平衡训练对PD患者皮层神经可塑性的影响尚不清楚。目的:探讨平衡训练对帕金森病患者皮质运动兴奋性的影响。方法:招募28名PD参与者,随机分为平衡训练组(BT)和对照组(CON)。两组在8周内进行了16次训练。皮质运动抑制的结果测量包括经颅磁刺激的皮质沉默期(CSP)和短间隔皮质内抑制(SICI)。平衡性能通过Mini-Balance评估系统测试(Mini-BEST)和Timed Up and Go (TUG)测试来测量。结果:BT组受试者皮质运动抑制显著升高(CSP: P =。028, SICI: P = .04)和平衡性能的显着改善(Mini-BEST: P =。001, TUG: P = .04)。与CON组相比,BT组皮质运动抑制明显增加(CSP: P =。017, SICI: P = .046)和更好的平衡改善(Mini-BEST: P = .046)。结论:平衡训练可以调节初级运动皮层的皮质运动抑制,提高PD患者的平衡能力。
Balance Training Modulates Cortical Inhibition in Individuals with Parkinson's Disease: A Randomized Controlled Trial.
Background: Most individuals with Parkinson's disease (PD) develop balance dysfunction. Previous studies showed that individuals with PD have abnormal corticomotor changes related to severity of motor symptoms and disease progression. Cortical disinhibition was observed in PD and this alteration can be an early sign of PD. Balance training seems to be an effective intervention to improve balance in individuals with PD. However, it is not much known about the effect of balance training on cortical neuroplasticity in PD population.
Objective: To investigate the effects of balance training on corticomotor excitability in individuals with PD.
Methods: Twenty-eight PD participants were recruited and randomly assigned to either the balance training (BT) or the control (CON) group. Both groups underwent 16 training sessions over 8 weeks. Outcome measures for corticomotor inhibition included the cortical silent period (CSP) and short-interval intracortical inhibition (SICI) on transcranial magnetic stimulation. Balance performance was measured using the Mini-Balance Evaluation Systems Test (Mini-BEST) and the Timed Up and Go (TUG) test.
Results: Participants in the BT group showed a significant increase in corticomotor inhibition (CSP: P = .028, SICI: P = .04) and a significant improvement in balance performance (Mini-BEST: P = .001, TUG: P = .04) after training. Compared to the CON group, the BT group showed a greater increase in corticomotor inhibition (CSP: P = .017, SICI: P = .046) and better improvement in balance (Mini-BEST: P = .046).
Conclusion: Balance training could modulate corticomotor inhibition in the primary motor cortex and improve balance performance in individuals with PD.
期刊介绍:
Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal''s unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer''s disease, brain and spinal cord injuries, and peripheral nerve injuries.