aim2炎性体在系统性红斑狼疮和类风湿关节炎中的作用。

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Autoimmunity Pub Date : 2022-11-01 Epub Date: 2022-07-26 DOI:10.1080/08916934.2022.2103802
E E Uresti-Rivera, M H García-Hernández
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引用次数: 2

摘要

炎症小体AIM2调节先天免疫功能的多个方面,并作为炎症反应的关键介质。AIM2炎性小体的激活导致促炎细胞因子IL-1β和IL-18的产生,并参与触发对抗过度细胞增殖所需的焦亡反应。此外,AIM2的表达和激活受到广泛调控,因为其活性的改变可能源于病理后果。因此,失调的AIM2激活有助于各种炎症性疾病的致病过程。在这篇综述中,我们将讨论AIM2炎性体的激活和功能,以及它在类风湿关节炎和系统性红斑狼疮病理中的作用。最后,我们强调了aim2 -炎性体在类风湿关节炎的关节水平和系统性红斑狼疮的肾脏水平的参与。基于调节aim2炎性小体活性的治疗策略的发展应该具有组织特异性的重点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis.

The inflammasome AIM2 regulates multiple aspects of innate immune functions and serves as a critical mediator of inflammatory responses. AIM2 inflammasome activation leads to the production of pro-inflammatory cytokines, IL-1β and IL-18 and participates triggering a pyroptosis response needed to counteract excessive cell proliferation. In addition, AIM2 expression and activation is wide regulated since alteration in its activity may derived in pathological consequences. Consequently, deregulated AIM2 activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will discuss the activation and function of AIM2 inflammasome, as well as its contribution in rheumatoid arthritis and systemic lupus erythematous pathology. Finally, we highlight the participation of the AIM2-inflammasome at the level of joint in rheumatoid arthritis and at kidney in systemic lupus erythematous. The development of therapeutic strategies based on modulation of AIM2-inflammasome activity should have a tissue-specific focus.

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来源期刊
Autoimmunity
Autoimmunity 医学-免疫学
CiteScore
5.70
自引率
8.60%
发文量
59
审稿时长
6-12 weeks
期刊介绍: Autoimmunity is an international, peer reviewed journal that publishes articles on cell and molecular immunology, immunogenetics, molecular biology and autoimmunity. Current understanding of immunity and autoimmunity is being furthered by the progress in new molecular sciences that has recently been little short of spectacular. In addition to the basic elements and mechanisms of the immune system, Autoimmunity is interested in the cellular and molecular processes associated with systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, type I diabetes, multiple sclerosis and other systemic and organ-specific autoimmune disorders. The journal reflects the immunology areas where scientific progress is most rapid. It is a valuable tool to basic and translational researchers in cell biology, genetics and molecular biology of immunity and autoimmunity.
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