舌下舒芬太尼与静脉注射芬太尼在门诊手术中心治疗急性术后疼痛:一项随机临床试验

IF 1.6 Q2 ANESTHESIOLOGY
Anesthesiology Research and Practice Pub Date : 2022-07-08 eCollection Date: 2022-01-01 DOI:10.1155/2022/5237877
Aaron Berg, Jason Habeck, Michael Strigenz, Jonah Pearson, Alexander Kaizer, Jacob Hutchins
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引用次数: 0

摘要

目的:舌下舒芬太尼是一种治疗术后中重度疼痛的新型阿片类药物。本研究的目的是确定单剂量舌下舒芬太尼片(SST)是否与单剂量静脉注射(IV)芬太尼在门诊手术出院时一样有效。方法:这是一项在一个独立的门诊手术中心进行的双臂、平行组、随机前瞻性研究。年龄在18-80岁、术后疼痛评分≥4的全身麻醉患者被纳入研究,随机接受30 mcg SST或50 mcg IV芬太尼。在初始随机剂量后,如果需要,救援IV芬太尼,然后口服羟考酮。根据第二阶段出院标准,从到达麻醉后护理病房到准备出院标准的康复时间。结果:分析75例患者。两组从恢复室出院的准备程度无显著差异(静脉注射芬太尼的中位时间为65分钟;IQR 56 - 89;SST 73 min, IQR 58-89;p = 0.903)。两组急救阿片类药物所需吗啡当量(MME)无显著差异(IV芬太尼抢救MME中位数为22.5,IQR为13.1-23.4;SST中位抢救MME为15.0,IQR为7.5 ~ 30.0;p = 0.742)。PACU初始疼痛和出院时疼痛变化无显著差异(IV芬太尼初始疼痛减去出院时疼痛中位数3,IQR 2-4;SST初痛减出院痛中位数4,IQR 2 ~ 5.5;p = 0.079)。在六项筛选和镇痛药调查评分的总体受益方面没有差异。讨论。综上所述,与静脉注射芬太尼50 mcg相比,接受舌下舒芬太尼30 mcg片剂的患者在PACU停留时间或抢救镇痛药使用方面没有显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sublingual Sufentanil vs. Intravenous Fentanyl for the Treatment of Acute Postoperative Pain in the Ambulatory Surgery Center: A Randomized Clinical Trial.

Sublingual Sufentanil vs. Intravenous Fentanyl for the Treatment of Acute Postoperative Pain in the Ambulatory Surgery Center: A Randomized Clinical Trial.

Objectives: Sublingual sufentanil is a novel opioid medication to treat moderate to severe pain postoperatively. This study's aim was to determine if a single dose of a sublingual sufentanil tablet (SST) is as efficacious as a single dose of intravenous (IV) fentanyl in readiness to discharge from ambulatory surgery.

Methods: This was a two-arm, parallel group, randomized prospective outcomes study conducted at a single, free-standing ambulatory surgery center. Patients aged 18-80 undergoing general anesthesia who developed a postoperative pain score of ≥ 4 were enrolled and randomized to receive either 30 mcg SST or 50 mcg IV fentanyl. After their initial randomized dose, rescue IV fentanyl followed by oral oxycodone if needed. Recovery length of stay from arrival in the postanesthesia care unit until readiness to discharge criteria was met based on phase 2 discharge criteria.

Results: 75 patients were analyzed. Readiness to discharge from the recovery room was not significantly different between either group (IV fentanyl median 65 minutes; IQR 56-89; SST 73 min, IQR 58-89; p=0.903). There was no significant difference in the amount of morphine equivalents (MME) of rescue opioids needed (IV fentanyl median rescue MME of 22.5, IQR 13.1-23.4; SST median rescue MME of 15.0, IQR 7.5-30.0; p=0.742). The change in pain from PACU initially, and on discharge was not significantly different (IV fentanyl initial pain minus pain on discharge median 3, IQR 2-4; SST initial pain minus pain on discharge median 4, IQR 2-5.5; p=0.079). There was no difference in the six-item screener and the Overall Benefit of Analgesic Survey Score. Discussion. In conclusion, patients who received a sublingual sufentanil 30 mcg tablet had no significant differences in PACU length of stay or rescue analgesic usage when compared to intravenous fentanyl 50 mcg.

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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
29
审稿时长
18 weeks
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