泛素特异性蛋白酶8基因在散发性垂体腺瘤中的表达。

IF 0.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Neuro endocrinology letters Pub Date : 2022-06-05

Esra Hatipoglu, Omur Gunaldi, Buruc Erkan, Ayla Avcikurt, Meral Mert, Mutlu Niyazoglu

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引用次数: 0

摘要

目的:在散发性垂体腺瘤中，泛素特异性蛋白酶8 (USP8)的作用尚不明确。已知USP8基因突变影响皮质性腺瘤的形成。然而，USP8表达的改变是否对其他垂体腺瘤有影响尚不清楚。在这项研究中，我们研究了垂体腺瘤(PA)中USP8基因表达水平相对于非腺瘤脑组织的变化。材料和方法:对43例人垂体腺瘤组织样本和16例非垂体脑组织(对照组)组织样本进行USP8基因表达分析。评估腺瘤组织和对照组织USP8的RNA表达量。测定与对照组相比USP8基因表达水平。结果:总体而言，PA中USP8基因表达水平比对照脑组织(CBT)高3.7倍(p=0.002)。然而，分层后，只有分泌性PA的USP8高于CBT(p=0.002)。结论:目前的研究结果支持USP8基因表达水平可能参与垂体肿瘤的发生和激素的产生。

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Ubiquitin-specific Protease 8 Gene Expression in Sporadic Pituitary Adenomas.

Objectives: In sporadic pituitary adenomas, the role of Ubiquitin-specific protease 8 (USP8) is not clearly defined. Mutations in USP8 gene are known to influence formation of the corticotroph adenomas. However, it has not been clarified whether changes in expression of USP8 have an impact on other pituitary adenomas or not. In this study we addressed the changes in USP8 gene expression levels in pituitary adenomas (PA) relative to non-adenomatous brain tissue.

Material and methods: USP8 gene expression analysis was performed on a total of 43 tissue samples from human pituitary adenomas and on 16 tissue samples from non-pituitary brain tissues (control group). Adenomatous tissues and control tissues were assessed for quantification of RNA expression of USP8.The levels of USP8 gene expression were determined relative to those in control group.

Results: Overall, the USP8 gene expression levels in PA were 3.7 times higher than the control brain tissues (CBT) (p=0.002). However, after stratification, only the USP8 in the secretory PA were higher than CBT(p=0.002).

Conclusions: Present findings support that USP8 gene expression levels may contribute to pitutary tumorigenesis and hormonogenesis..

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来源期刊

Neuro endocrinology letters 医学-内分泌学与代谢

CiteScore

1.00

自引率

14.30%

发文量

审稿时长

6 months

期刊介绍： Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology Letters. Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered. The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.