Moamen Shalkamy Abdelgawaad Shalkamy, Jung Hoon Bae, Chul Seung Lee, Seung Rim Han, Ji Hoon Kim, Bong-Hyeon Kye, In Kyu Lee, Yoon Suk Lee
{"title":"结肠癌血管浸润的肿瘤学影响可能因肿瘤的侧边性而异。","authors":"Moamen Shalkamy Abdelgawaad Shalkamy, Jung Hoon Bae, Chul Seung Lee, Seung Rim Han, Ji Hoon Kim, Bong-Hyeon Kye, In Kyu Lee, Yoon Suk Lee","doi":"10.7602/jmis.2022.25.2.53","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Vascular invasion is a well-known independent prognostic factor in colon cancer and tumor sidedness is also being considered a prognostic factor. The aim of this study was to compare the oncological impact of vascular invasion depending on the tumor location in stages I to III colon cancer.</p><p><strong>Methods: </strong>A retrospective analysis was performed using data from patients who underwent curative resection between 2004 and 2015. Patients were divided into right-sided colon cancer (RCC) and left-sided colon cancer (LCC) groups according to the tumor location. Disease-free survival (DFS) and overall survival (OS) were compared between the RCC and LCC groups, depending on the presence of vascular invasion.</p><p><strong>Results: </strong>A total of 793 patients were included, of which 304 (38.3%) had RCC and 489 (61.7%) had LCC. DFS and OS did not differ significantly between the RCC and LCC groups. Vascular invasion was a poor prognostic factor for DFS in both RCC (hazard ratio [HR], 2.291; 95% confidence interval [CI], 1.186-4.425; <i>p</i> = 0.010) and LCC (HR, 1.848; 95% CI, 1.139-2.998; <i>p</i> = 0.011). Additionally, it was associated with significantly worse OS in the RCC (HR, 3.503; 95% CI, 1.681-7.300; <i>p</i> < 0.001), but not in the LCC group (HR, 1.676; 95% CI, 0.885-3.175; <i>p</i> = 0.109). Multivariate analysis revealed that vascular invasion was independently poor prognostic factor for OS in the RCC (HR, 3.186; 95% CI, 1.391-7.300; <i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>This study demonstrated that RCC with vascular invasion had worse OS than LCC with vascular invasion.</p>","PeriodicalId":73832,"journal":{"name":"Journal of minimally invasive surgery","volume":"25 2","pages":"53-62"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/b1/jmis-25-2-53.PMC9218406.pdf","citationCount":"2","resultStr":"{\"title\":\"Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness.\",\"authors\":\"Moamen Shalkamy Abdelgawaad Shalkamy, Jung Hoon Bae, Chul Seung Lee, Seung Rim Han, Ji Hoon Kim, Bong-Hyeon Kye, In Kyu Lee, Yoon Suk Lee\",\"doi\":\"10.7602/jmis.2022.25.2.53\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Vascular invasion is a well-known independent prognostic factor in colon cancer and tumor sidedness is also being considered a prognostic factor. The aim of this study was to compare the oncological impact of vascular invasion depending on the tumor location in stages I to III colon cancer.</p><p><strong>Methods: </strong>A retrospective analysis was performed using data from patients who underwent curative resection between 2004 and 2015. Patients were divided into right-sided colon cancer (RCC) and left-sided colon cancer (LCC) groups according to the tumor location. Disease-free survival (DFS) and overall survival (OS) were compared between the RCC and LCC groups, depending on the presence of vascular invasion.</p><p><strong>Results: </strong>A total of 793 patients were included, of which 304 (38.3%) had RCC and 489 (61.7%) had LCC. DFS and OS did not differ significantly between the RCC and LCC groups. Vascular invasion was a poor prognostic factor for DFS in both RCC (hazard ratio [HR], 2.291; 95% confidence interval [CI], 1.186-4.425; <i>p</i> = 0.010) and LCC (HR, 1.848; 95% CI, 1.139-2.998; <i>p</i> = 0.011). Additionally, it was associated with significantly worse OS in the RCC (HR, 3.503; 95% CI, 1.681-7.300; <i>p</i> < 0.001), but not in the LCC group (HR, 1.676; 95% CI, 0.885-3.175; <i>p</i> = 0.109). Multivariate analysis revealed that vascular invasion was independently poor prognostic factor for OS in the RCC (HR, 3.186; 95% CI, 1.391-7.300; <i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>This study demonstrated that RCC with vascular invasion had worse OS than LCC with vascular invasion.</p>\",\"PeriodicalId\":73832,\"journal\":{\"name\":\"Journal of minimally invasive surgery\",\"volume\":\"25 2\",\"pages\":\"53-62\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/b1/jmis-25-2-53.PMC9218406.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of minimally invasive surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7602/jmis.2022.25.2.53\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of minimally invasive surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7602/jmis.2022.25.2.53","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Oncological impact of vascular invasion in colon cancer might differ depending on tumor sidedness.
Purpose: Vascular invasion is a well-known independent prognostic factor in colon cancer and tumor sidedness is also being considered a prognostic factor. The aim of this study was to compare the oncological impact of vascular invasion depending on the tumor location in stages I to III colon cancer.
Methods: A retrospective analysis was performed using data from patients who underwent curative resection between 2004 and 2015. Patients were divided into right-sided colon cancer (RCC) and left-sided colon cancer (LCC) groups according to the tumor location. Disease-free survival (DFS) and overall survival (OS) were compared between the RCC and LCC groups, depending on the presence of vascular invasion.
Results: A total of 793 patients were included, of which 304 (38.3%) had RCC and 489 (61.7%) had LCC. DFS and OS did not differ significantly between the RCC and LCC groups. Vascular invasion was a poor prognostic factor for DFS in both RCC (hazard ratio [HR], 2.291; 95% confidence interval [CI], 1.186-4.425; p = 0.010) and LCC (HR, 1.848; 95% CI, 1.139-2.998; p = 0.011). Additionally, it was associated with significantly worse OS in the RCC (HR, 3.503; 95% CI, 1.681-7.300; p < 0.001), but not in the LCC group (HR, 1.676; 95% CI, 0.885-3.175; p = 0.109). Multivariate analysis revealed that vascular invasion was independently poor prognostic factor for OS in the RCC (HR, 3.186; 95% CI, 1.391-7.300; p = 0.006).
Conclusion: This study demonstrated that RCC with vascular invasion had worse OS than LCC with vascular invasion.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
