Sophia Mt Dinges, Janosch Krotz, Felix Gass, Julian Treitschke, Isabel Fegers-Wustrow, Marisa Geisberger, Katrin Esefeld, Pia von Korn, André Duvinage, Frank Edelmann, Oliver Wolfram, Julia Brandts, Ephraim B Winzer, Bernd Wolfarth, Felix Freigang, Sarah Neubauer, Thomas Nebling, Björn Hackenberg, Volker Amelung, Stephan Mueller, Martin Halle
{"title":"德国慢性缺血性心脏病和2型糖尿病患者的心血管危险因素、运动能力和健康素养:慢性缺血性心脏病和2型糖尿病研究中生活方式干预的基线特征","authors":"Sophia Mt Dinges, Janosch Krotz, Felix Gass, Julian Treitschke, Isabel Fegers-Wustrow, Marisa Geisberger, Katrin Esefeld, Pia von Korn, André Duvinage, Frank Edelmann, Oliver Wolfram, Julia Brandts, Ephraim B Winzer, Bernd Wolfarth, Felix Freigang, Sarah Neubauer, Thomas Nebling, Björn Hackenberg, Volker Amelung, Stephan Mueller, Martin Halle","doi":"10.1177/14791641221113781","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lifestyle interventions are a cornerstone in the treatment of chronic ischaemic heart disease (CIHD) and type 2 diabetes mellitus (T2DM). This study aimed at identifying differences in clinical characteristics between categories of the common lifestyle intervention targets BMI, exercise capacity (peak V̇O<sub>2</sub>) and health literacy (HL).</p><p><strong>Methods: </strong>Cross-sectional baseline characteristics of patients enrolled in the LeIKD trial (Clinicaltrials.gov NCT03835923) are presented in total, grouped by BMI, %-predicted peak V̇O<sub>2</sub> and HL (HLS-EU-Q16), and compared to other clinical trials with similar populations.</p><p><strong>Results: </strong>Among 499 patients (68.3±7.7 years; 16.2% female; HbA1c, 6.9±0.9%), baseline characteristics were similar to other trials and revealed insufficient treatment of several risk factors (LDL-C 92±34 mg/dl; BMI, 30.1±4.8 kg/m<sup>2</sup>; 69.6% with peak V̇O<sub>2</sub><90% predicted). Patients with lower peak V̇O<sub>2</sub> showed significantly higher (<i>p</i> < 0.05) CIHD and T2DM disease severity (HbA1c, CIHD symptoms, coronary artery bypass graft). Obese patients had a significantly higher prevalence of hypertension and higher triglyceride levels, whereas in patients with low HL both quality of life components (physical, mental) were significantly reduced.</p><p><strong>Conclusions: </strong>In patients with CIHD and T2DM, peak V̇O2, BMI and HL are important indicators of disease severity, risk factor burden and quality of life, which reinforces the relevance of lifestyle interventions.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":" ","pages":"14791641221113781"},"PeriodicalIF":2.8000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/43/10.1177_14791641221113781.PMC9379969.pdf","citationCount":"0","resultStr":"{\"title\":\"Cardiovascular risk factors, exercise capacity and health literacy in patients with chronic ischaemic heart disease and type 2 diabetes mellitus in Germany: Baseline characteristics of the Lifestyle Intervention in Chronic Ischaemic Heart Disease and Type 2 Diabetes study.\",\"authors\":\"Sophia Mt Dinges, Janosch Krotz, Felix Gass, Julian Treitschke, Isabel Fegers-Wustrow, Marisa Geisberger, Katrin Esefeld, Pia von Korn, André Duvinage, Frank Edelmann, Oliver Wolfram, Julia Brandts, Ephraim B Winzer, Bernd Wolfarth, Felix Freigang, Sarah Neubauer, Thomas Nebling, Björn Hackenberg, Volker Amelung, Stephan Mueller, Martin Halle\",\"doi\":\"10.1177/14791641221113781\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Lifestyle interventions are a cornerstone in the treatment of chronic ischaemic heart disease (CIHD) and type 2 diabetes mellitus (T2DM). This study aimed at identifying differences in clinical characteristics between categories of the common lifestyle intervention targets BMI, exercise capacity (peak V̇O<sub>2</sub>) and health literacy (HL).</p><p><strong>Methods: </strong>Cross-sectional baseline characteristics of patients enrolled in the LeIKD trial (Clinicaltrials.gov NCT03835923) are presented in total, grouped by BMI, %-predicted peak V̇O<sub>2</sub> and HL (HLS-EU-Q16), and compared to other clinical trials with similar populations.</p><p><strong>Results: </strong>Among 499 patients (68.3±7.7 years; 16.2% female; HbA1c, 6.9±0.9%), baseline characteristics were similar to other trials and revealed insufficient treatment of several risk factors (LDL-C 92±34 mg/dl; BMI, 30.1±4.8 kg/m<sup>2</sup>; 69.6% with peak V̇O<sub>2</sub><90% predicted). Patients with lower peak V̇O<sub>2</sub> showed significantly higher (<i>p</i> < 0.05) CIHD and T2DM disease severity (HbA1c, CIHD symptoms, coronary artery bypass graft). Obese patients had a significantly higher prevalence of hypertension and higher triglyceride levels, whereas in patients with low HL both quality of life components (physical, mental) were significantly reduced.</p><p><strong>Conclusions: </strong>In patients with CIHD and T2DM, peak V̇O2, BMI and HL are important indicators of disease severity, risk factor burden and quality of life, which reinforces the relevance of lifestyle interventions.</p>\",\"PeriodicalId\":11092,\"journal\":{\"name\":\"Diabetes & Vascular Disease Research\",\"volume\":\" \",\"pages\":\"14791641221113781\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2022-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/43/10.1177_14791641221113781.PMC9379969.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes & Vascular Disease Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/14791641221113781\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes & Vascular Disease Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/14791641221113781","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Cardiovascular risk factors, exercise capacity and health literacy in patients with chronic ischaemic heart disease and type 2 diabetes mellitus in Germany: Baseline characteristics of the Lifestyle Intervention in Chronic Ischaemic Heart Disease and Type 2 Diabetes study.
Background: Lifestyle interventions are a cornerstone in the treatment of chronic ischaemic heart disease (CIHD) and type 2 diabetes mellitus (T2DM). This study aimed at identifying differences in clinical characteristics between categories of the common lifestyle intervention targets BMI, exercise capacity (peak V̇O2) and health literacy (HL).
Methods: Cross-sectional baseline characteristics of patients enrolled in the LeIKD trial (Clinicaltrials.gov NCT03835923) are presented in total, grouped by BMI, %-predicted peak V̇O2 and HL (HLS-EU-Q16), and compared to other clinical trials with similar populations.
Results: Among 499 patients (68.3±7.7 years; 16.2% female; HbA1c, 6.9±0.9%), baseline characteristics were similar to other trials and revealed insufficient treatment of several risk factors (LDL-C 92±34 mg/dl; BMI, 30.1±4.8 kg/m2; 69.6% with peak V̇O2<90% predicted). Patients with lower peak V̇O2 showed significantly higher (p < 0.05) CIHD and T2DM disease severity (HbA1c, CIHD symptoms, coronary artery bypass graft). Obese patients had a significantly higher prevalence of hypertension and higher triglyceride levels, whereas in patients with low HL both quality of life components (physical, mental) were significantly reduced.
Conclusions: In patients with CIHD and T2DM, peak V̇O2, BMI and HL are important indicators of disease severity, risk factor burden and quality of life, which reinforces the relevance of lifestyle interventions.
期刊介绍：
Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)
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