h型高血压患者早峰现象与早期肾损伤NGAL的关系。

IF 2.3 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Blood Pressure Pub Date : 2022-12-01 DOI:10.1080/08037051.2022.2106186

Chi Zhang, Dan-Dan Zhang, Yu-Mei Feng, Zhan-Qiang Huang, Yun-Bo Xie, Jian Zhou, Jun Li

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引用次数: 3

摘要

目的:探讨h型高血压患者晨起血压升高(MBPS)与中性粒细胞明胶酶相关脂钙蛋白(NGAL)的关系。材料与方法:选取确诊为h型高血压[同型半胱氨酸(Hcy)≧10umol/L]的患者224例，进行24小时动态血压监测(ABPM)。早峰组(115例)检测各组NGAL、血清胱抑素C、β2微球蛋白水平，并检测一般生化指标。结果:两组患者高血压病程、年龄、血糖、血脂、Hcy、BUN、Cr、UA比较，差异无统计学意义(p > 0.05)。CysC、β2-MG均高于非晨峰组，且差异有统计学意义(p β2-MG、p > 0.05);多元线性逐步回归分析表明，晨峰收缩压、CysC、β2-MG、FBG是NGAL发生的危险因素。结论:h型高血压患者收缩压晨峰是引起肾损伤的重要因素。重视h型高血压患者的动态血压监测和晨峰血压控制，早期筛查NGAL对h型高血压患者早期预防和治疗肾损伤具有重要的临床意义。摘要早晨血压峰值与靶器官损伤密切相关。国内外关于h型高血压患者晨峰现象与肾损害关系的研究较少。探讨BUN、Cr、UA均在正常范围内的h型高血压患者MBPS与NGAL的关系，为高血压患者早期肾保护提供临床依据。

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Relationship between morning peak phenomenon and early renal injury NGAL in H-type hypertension.

Purpose: To investigate the relationship between morning blood pressure surge (MBPS) and neutrophilgelatinase associated lipocalin (NGAL) in patients with H-type hypertension.

Materials and methods: A total of 224 patients with diagnosed H-type hypertension [homocysteine (Hcy)≧10umol/L] were selected and underwent 24-hour ambulatory blood pressure monitoring (ABPM). In the morning peak group (115 cases), NGAL and serum cystatin C levels, $β_{2}$ -microglobulin levels were detected in each group, and general biochemical indicators were also detected.

Results: There was no significant difference in the course of hypertension, age, blood glucose, blood lipids, Hcy, BUN, Cr, and UA between the two groups (p > 0.05). CysC, $β_{2}$ -MG were higher than those in the nonmorning peak group, and the difference was statistically significant (p < 0.05).; Pearson correlation analysis showed that NGAL was moderately and highly correlated with CysC, systolic blood pressure morning peak, $β_{2}$ -MG, and high (p < 0.05), low-density lipoprotein (LDL-C), and Hcy were lowly correlated (p < 0.05).) and morning peak diastolic blood pressure (p > 0.05); multiple linear stepwise regression analysis indicated that morning peak systolic blood pressure, CysC, $β_{2}$ -MG, and FBG were the risk factors for NGAL.

Conclusion: The morning peak of systolic blood pressure in H-type hypertension is an important factor causing kidney injury. Paying attention to the ambulatory blood pressure monitoring and the control of morning peak blood pressure in patients with H-type hypertension, and early screening of NGAL has important clinical significance for the early prevention and treatment of renal injury in patients with H-type hypertension. PLAIN LANGUAGE SUMMARYThe morning peak of blood pressure is closely related to target organ damage.There are few studies on the relationship between morning peak phenomenon and renal damage in patients with H-type hypertension at home and abroad.We investigated the relationship between MBPS and NGAL in H-type hypertensive patients with BUN, Cr and UA in the normal range to provide a clinical basis for early renal protection in hypertensive patients.

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来源期刊

Blood Pressure 医学-外周血管病

CiteScore

3.00

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： For outstanding coverage of the latest advances in hypertension research, turn to Blood Pressure, a primary source for authoritative and timely information on all aspects of hypertension research and management. Features include: • Physiology and pathophysiology of blood pressure regulation • Primary and secondary hypertension • Cerebrovascular and cardiovascular complications of hypertension • Detection, treatment and follow-up of hypertension • Non pharmacological and pharmacological management • Large outcome trials in hypertension.