{"title":"单核苷酸a -重复序列可能在吸热管家基因中起调节作用。","authors":"Jatuphol Pholtaisong, Nachol Chaiyaratana, Chatchawit Aporntewan, Apiwat Mutirangura","doi":"10.1177/11769343221110656","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals: <i>H. sapiens, M. musculus</i>, and <i>R. norvegicus</i>.</p><p><strong>Principal findings: </strong>We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed in mammals and birds, but not in amphibians and reptiles. We proposed that the enriched A-repeats upstream of TSSs is a novel hallmark of endotherms or warm-blooded animals. Gene ontology analysis indicates that the primary function of upstream A-repeats involves metabolism, cellular transportation, and sensory perception (smell and chemical stimulus) through housekeeping genes.</p><p><strong>Conclusions: </strong>Upstream A-repeats may play a regulatory role in the metabolic process of endothermic animals.</p>","PeriodicalId":136690,"journal":{"name":"Evolutionary Bioinformatics Online","volume":" ","pages":"11769343221110656"},"PeriodicalIF":0.0000,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/87/10.1177_11769343221110656.PMC9290108.pdf","citationCount":"0","resultStr":"{\"title\":\"Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes.\",\"authors\":\"Jatuphol Pholtaisong, Nachol Chaiyaratana, Chatchawit Aporntewan, Apiwat Mutirangura\",\"doi\":\"10.1177/11769343221110656\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals: <i>H. sapiens, M. musculus</i>, and <i>R. norvegicus</i>.</p><p><strong>Principal findings: </strong>We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed in mammals and birds, but not in amphibians and reptiles. We proposed that the enriched A-repeats upstream of TSSs is a novel hallmark of endotherms or warm-blooded animals. Gene ontology analysis indicates that the primary function of upstream A-repeats involves metabolism, cellular transportation, and sensory perception (smell and chemical stimulus) through housekeeping genes.</p><p><strong>Conclusions: </strong>Upstream A-repeats may play a regulatory role in the metabolic process of endothermic animals.</p>\",\"PeriodicalId\":136690,\"journal\":{\"name\":\"Evolutionary Bioinformatics Online\",\"volume\":\" \",\"pages\":\"11769343221110656\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/87/10.1177_11769343221110656.PMC9290108.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Evolutionary Bioinformatics Online\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1177/11769343221110656\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Evolutionary Bioinformatics Online","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1177/11769343221110656","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes.
Background: Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals: H. sapiens, M. musculus, and R. norvegicus.
Principal findings: We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed in mammals and birds, but not in amphibians and reptiles. We proposed that the enriched A-repeats upstream of TSSs is a novel hallmark of endotherms or warm-blooded animals. Gene ontology analysis indicates that the primary function of upstream A-repeats involves metabolism, cellular transportation, and sensory perception (smell and chemical stimulus) through housekeeping genes.
Conclusions: Upstream A-repeats may play a regulatory role in the metabolic process of endothermic animals.
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